Mouse Anti-ANTXR1 Recombinant Antibody (200C1339) (CBMAB-T0045-YJ)

Name: Mouse Anti-ANTXR1 Recombinant Antibody (200C1339)
SKU: CBMAB-T0045-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

200C1339

Application

WB, IP, IF, IHC-P

Immunogen

Amino acids 481-497 of TEM8 of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 481-497

More Infomation

Target

Full Name

Anthrax Toxin Receptor 1

Introduction

ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. ANTXR1 has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to ANTXR1 mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.

Entrez Gene ID

84168

UniProt ID

Q9H6X2

Alternative Names

Anthrax Toxin Receptor 1; Tumor Endothelial Marker 8; TEM8; ATR; Tumor Endothelial Marker 8 Precursor; Anthrax Toxin Receptor; 2310008J16Rik; 2810405N18Rik; GAPO

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Blood vessel development Source: Ensembl
Negative regulation of extracellular matrix assembly Source: Ensembl
Positive regulation of metallopeptidase activity Source: Ensembl
Reproductive process Source: Ensembl
Substrate adhesion-dependent cell spreading Source: UniProtKB
Toxin transport Source: GO_Central

Cellular Location

Cell membrane; Lamellipodium membrane; Filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

Involvement in disease

Hemangioma, capillary infantile (HCI): A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
GAPO syndrome (GAPOS): An autosomal recessive disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients.

Topology

Extracellular: 33-321 aa
Helical: 322-342 aa
Cytoplasmic: 343-564 aa

Li, Y., Wang, Q., Wang, D., & Fu, W. (2021). KLF7 Promotes Gastric Carcinogenesis Through Regulation of ANTXR1. Cancer Management and Research, 13, 5547.

Sotoudeh, M., Shakeri, R., Dawsey, S. M., Sharififard, B., Ahmadbeigi, N., & Naderi, M. (2019). ANTXR1 (TEM8) overexpression in gastric adenocarcinoma makes the protein a potential target of immunotherapy. Cancer Immunology, Immunotherapy, 68(10), 1597-1603.

Alcalá, S., Martinelli, P., Hermann, P. C., Heeschen, C., & Sainz, B. (2019). The anthrax toxin receptor 1 (ANTXR1) is enriched in pancreatic cancer stem cells derived from primary tumor cultures. Stem cells international, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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