Human ANTXR1 ELISA Kit (V2LY-0626-LY2946)

Name: Human ANTXR1 ELISA Kit
SKU: V2LY-0626-LY2946
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.015 ng/mL

Detection Range

0.03-9 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

62.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Anthrax Toxin Receptor 1

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Blood vessel development Source: Ensembl
Negative regulation of extracellular matrix assembly Source: Ensembl
Positive regulation of metallopeptidase activity Source: Ensembl
Reproductive process Source: Ensembl
Substrate adhesion-dependent cell spreading Source: UniProtKB
Toxin transport Source: GO_Central

Cellular Location

Cell membrane; Lamellipodium membrane; Filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

Involvement in disease

Hemangioma, capillary infantile (HCI): A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
GAPO syndrome (GAPOS): An autosomal recessive disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients.

Topology

Extracellular: 33-321 aa
Helical: 322-342 aa
Cytoplasmic: 343-564 aa

Li, Y., Wang, Q., Wang, D., & Fu, W. (2021). KLF7 Promotes Gastric Carcinogenesis Through Regulation of ANTXR1. Cancer Management and Research, 13, 5547.

Sotoudeh, M., Shakeri, R., Dawsey, S. M., Sharififard, B., Ahmadbeigi, N., & Naderi, M. (2019). ANTXR1 (TEM8) overexpression in gastric adenocarcinoma makes the protein a potential target of immunotherapy. Cancer Immunology, Immunotherapy, 68(10), 1597-1603.

Alcalá, S., Martinelli, P., Hermann, P. C., Heeschen, C., & Sainz, B. (2019). The anthrax toxin receptor 1 (ANTXR1) is enriched in pancreatic cancer stem cells derived from primary tumor cultures. Stem cells international, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ANTXR1 protein, hFc Tag (CAT#: V2LY-0526-LY7155)

Human Recombinant ANTXR1 protein, His Tag (CAT#: V2LY-0526-LY7156)

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Human Recombinant ANTXR1 protein, His Tag (CAT#: V2LY-0526-LY7156)

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Mouse Anti-ANTXR1 Recombinant Antibody (200C1339) (CAT#: CBMAB-T0045-YJ)

Mouse Anti-ANTXR1 Recombinant Antibody (CBYJT-1041) (CAT#: CBMAB-T0046-YJ)

Human Recombinant ANTXR1 protein, hFc Tag (CAT#: V2LY-0526-LY7155)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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