Human Recombinant ANTXR1 protein, His Tag (V2LY-0526-LY7156)

Name: Human Recombinant ANTXR1 protein, His Tag
SKU: V2LY-0526-LY7156
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ANTXR1 protein, His Tag consist of Amino Acid: 1-321 and predicts a molecular mass of 33.85 kDa.

Molecule Mass

33.85 kDa

Verified

HPLC

Sequence

Amino Acid: 1-321

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Anthrax Toxin Receptor 1

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Blood vessel development Source: Ensembl
Negative regulation of extracellular matrix assembly Source: Ensembl
Positive regulation of metallopeptidase activity Source: Ensembl
Reproductive process Source: Ensembl
Substrate adhesion-dependent cell spreading Source: UniProtKB
Toxin transport Source: GO_Central

Cellular Location

Cell membrane; Lamellipodium membrane; Filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

Involvement in disease

Hemangioma, capillary infantile (HCI): A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
GAPO syndrome (GAPOS): An autosomal recessive disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients.

Topology

Extracellular: 33-321 aa
Helical: 322-342 aa
Cytoplasmic: 343-564 aa

Li, Y., Wang, Q., Wang, D., & Fu, W. (2021). KLF7 Promotes Gastric Carcinogenesis Through Regulation of ANTXR1. Cancer Management and Research, 13, 5547.

Sotoudeh, M., Shakeri, R., Dawsey, S. M., Sharififard, B., Ahmadbeigi, N., & Naderi, M. (2019). ANTXR1 (TEM8) overexpression in gastric adenocarcinoma makes the protein a potential target of immunotherapy. Cancer Immunology, Immunotherapy, 68(10), 1597-1603.

Alcalá, S., Martinelli, P., Hermann, P. C., Heeschen, C., & Sainz, B. (2019). The anthrax toxin receptor 1 (ANTXR1) is enriched in pancreatic cancer stem cells derived from primary tumor cultures. Stem cells international, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ANTXR1 protein, hFc Tag (CAT#: V2LY-0526-LY7155)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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