Mouse Anti-ANXA3 Recombinant Antibody (4F1) (CBMAB-A2913-YC)

Name: Mouse Anti-ANXA3 Recombinant Antibody (4F1)
SKU: CBMAB-A2913-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-ANXA3 Recombinant Antibody (4F1) in WB

Total RNAs and total cell lysates were subjected to RTPCR and western blotting, respectively. ...View More

Watanabe, T., Ito, Y., Sato, A., Hosono, T., Niimi, S., Ariga, T., & Seki, T. (2012). Annexin A3 as a negative regulator of adipocyte differentiation. The journal of biochemistry, 152(4), 355-363.

Mouse Anti-ANXA3 Recombinant Antibody (4F1) in IF

Localization of annexin A3 in mouse adipose tissue. Serially prepared adipose tissue sections (3 mm) from mouse epididymal adipose tissue were immunohistochemically analysed. A section stained with H&E [A and E (higher magnification of 'A')] and with the combination of anti-human annexin A3 and FITC-labelled secondary antibody (B) and with that of monoclonal antibody against Dlk/Pref-1 and Cy3-labelled secondary antibody (C) are shown. Photo 'D' and its higher magnification, 'F' are merged images of photos 'B' and 'C.' The cell indicated by the arrowhead in photos 'E' and 'F' is a 2X-magnification of the arrowhead-marked cell in photos A and D, respectively. Arrowheads in panels 'A', 'D,' 'E', and 'F' indicate a cell positive for both annexin A3 and Dlk/Pref-1. Scale bars represent 10 um (A-D) and 5 um (E, F). ...View More

Watanabe, T., Ito, Y., Sato, A., Hosono, T., Niimi, S., Ariga, T., & Seki, T. (2012). Annexin A3 as a negative regulator of adipocyte differentiation. The journal of biochemistry, 152(4), 355-363.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F1

Application

ELISA, RNAi, WB

Immunogen

ANXA3 (AAH00871, 1-323 aa) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-323

More Infomation

Target

Full Name

Annexin A3

Introduction

ANXA3 is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A

Entrez Gene ID

306

UniProt ID

P12429

Alternative Names

Annexin A3; Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase; Placental Anticoagulant Protein III; 35-Alpha Calcimedin; Lipocortin III; Annexin-3; PAP-III;

Function

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Biological Process

Animal organ regeneration Source: Ensembl
Defense response to bacterium Source: UniProtKB
Hippocampus development Source: Ensembl
Neutrophil degranulation Source: UniProtKB
Phagocytosis Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of DNA metabolic process Source: Ensembl
Positive regulation of endothelial cell migration Source: UniProtKB
Response to glucocorticoid Source: Ensembl
Response to growth factor Source: Ensembl

Cellular Location

Extracellular exosome; Plasma membrane; Axon; Cytoplasm; Dendrite; Membrane; Neuronal cell body; Phagocytic vesicle membrane; Specific granule

Zhang, Z., Li, Z., Ma, Z., Deng, M., Xing, M., Wu, J., ... & Zou, W. (2021). Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats. Neural Plasticity, 2021.

Xu, B., Zhang, X., Gao, Y., Song, J., & Shi, B. (2021). Microglial Annexin A3 promoted the development of melanoma via activation of hypoxia‐inducible factor‐1α/vascular endothelial growth factor signaling pathway. Journal of Clinical Laboratory Analysis, 35(2), e23622.

Toufiq, M., Roelands, J., Alfaki, M., Syed Ahamed Kabeer, B., Saadaoui, M., Lakshmanan, A. P., ... & Garand, M. (2020). Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data. Immunology, 161(4), 291-302.

Huang, K., Crist, A. M., Patel, N. R., Blanks, A., Carter, K., Cleaver, O., & Meadows, S. M. (2020). Annexin A3 is necessary for parallel artery‐vein alignment in the mouse retina. Developmental Dynamics, 249(5), 666-678.

Zeng, X., Wang, S., Gui, P., Wu, H., & Li, Z. (2019). Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS. Molecular medicine reports, 20(3), 2583-2590.

Xu, R., Yin, J., Zhang, Y., & Zhang, S. (2019). Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway. Journal of cellular biochemistry, 120(9), 14585-14593.

Meng, H., Zhang, Y., An, S. T., & Chen, Y. (2019). Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction. Journal of cellular physiology, 234(7), 10535-10546.

Du, R., Liu, B., Zhou, L., Wang, D., He, X., Xu, X., ... & Liu, S. (2018). Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell death & disease, 9(2), 1-11.

Tong, M., Che, N., Zhou, L., Luk, S. T., Kau, P. W., Chai, S., ... & Ma, S. (2018). Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. Journal of hepatology, 69(4), 826-839.

Ma, X. L., Jiang, M., Zhao, Y., Wang, B. L., Shen, M. N., Zhou, Y., ... & Guo, W. (2018). Application of serum annexin A3 in diagnosis, outcome prediction and therapeutic response evaluation for patients with hepatocellular carcinoma. Annals of surgical oncology, 25(6), 1686-1694.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ANXA3 Matched Antibody Pair (079) (CAT#: APMAB-079LY)

ANXA3 Matched Antibody Pair (080) (CAT#: APMAB-080LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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