Human ANXA3 ELISA Kit (V2LY-0626-LY3743)

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Tested Data
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Basic Information

Sensitivity
0.055 ng/mL
Detection Range
0.1-35 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
36.4 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Annexin A3
Function
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
Biological Process
Animal organ regeneration Source: Ensembl
Defense response to bacterium Source: UniProtKB
Hippocampus development Source: Ensembl
Neutrophil degranulation Source: UniProtKB
Phagocytosis Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of DNA metabolic process Source: Ensembl
Positive regulation of endothelial cell migration Source: UniProtKB
Response to glucocorticoid Source: Ensembl
Response to growth factor Source: Ensembl
Cellular Location
Extracellular exosome; Plasma membrane; Axon; Cytoplasm; Dendrite; Membrane; Neuronal cell body; Phagocytic vesicle membrane; Specific granule

Zhang, Z., Li, Z., Ma, Z., Deng, M., Xing, M., Wu, J., ... & Zou, W. (2021). Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats. Neural Plasticity, 2021.

Xu, B., Zhang, X., Gao, Y., Song, J., & Shi, B. (2021). Microglial Annexin A3 promoted the development of melanoma via activation of hypoxia‐inducible factor‐1α/vascular endothelial growth factor signaling pathway. Journal of Clinical Laboratory Analysis, 35(2), e23622.

Toufiq, M., Roelands, J., Alfaki, M., Syed Ahamed Kabeer, B., Saadaoui, M., Lakshmanan, A. P., ... & Garand, M. (2020). Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data. Immunology, 161(4), 291-302.

Huang, K., Crist, A. M., Patel, N. R., Blanks, A., Carter, K., Cleaver, O., & Meadows, S. M. (2020). Annexin A3 is necessary for parallel artery‐vein alignment in the mouse retina. Developmental Dynamics, 249(5), 666-678.

Zeng, X., Wang, S., Gui, P., Wu, H., & Li, Z. (2019). Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS. Molecular medicine reports, 20(3), 2583-2590.

Xu, R., Yin, J., Zhang, Y., & Zhang, S. (2019). Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway. Journal of cellular biochemistry, 120(9), 14585-14593.

Meng, H., Zhang, Y., An, S. T., & Chen, Y. (2019). Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction. Journal of cellular physiology, 234(7), 10535-10546.

Du, R., Liu, B., Zhou, L., Wang, D., He, X., Xu, X., ... & Liu, S. (2018). Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell death & disease, 9(2), 1-11.

Tong, M., Che, N., Zhou, L., Luk, S. T., Kau, P. W., Chai, S., ... & Ma, S. (2018). Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. Journal of hepatology, 69(4), 826-839.

Ma, X. L., Jiang, M., Zhao, Y., Wang, B. L., Shen, M. N., Zhou, Y., ... & Guo, W. (2018). Application of serum annexin A3 in diagnosis, outcome prediction and therapeutic response evaluation for patients with hepatocellular carcinoma. Annals of surgical oncology, 25(6), 1686-1694.

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For research use only. Not intended for any clinical use.

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