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Mouse Anti-ANXA3 Recombinant Antibody (CBYC-A629) (CBMAB-A2918-YC)

Provided herein is a Mouse monoclonal antibody against Human Annexin A3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ANXA3 antibodies
Published Data
Mouse Anti-ANXA3 Recombinant Antibody (CBYC-A629) in WB
Cellular content in endogenous ANXA1 to A4 in LHCN myoblasts (Mb) and myotubes (MT) was quantified through western blot analysis. Black arrows indicate bands corresponding to ANX. The four western blot experiments were performed simultaneously with the same protein extracts (10 µg). ...View More
Croissant, C., Gounou, C., Bouvet, F., Tan, S., & Bouter, A. (2022). Trafficking of annexins during membrane repair in human skeletal muscle cells. Membranes, 12(2), 153.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYC-A629
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IHC-P, IF, IP

Basic Information

Immunogen
Amino acids 1-50 mapping at the N-terminus of Annexin III of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Annexin A3
Introduction
ANXA3 is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A
Entrez Gene ID
306
UniProt ID
P12429
Alternative Names
Annexin A3; Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase; Placental Anticoagulant Protein III; 35-Alpha Calcimedin; Lipocortin III; Annexin-3; PAP-III;
Function
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
Biological Process
Animal organ regeneration Source: Ensembl
Defense response to bacterium Source: UniProtKB
Hippocampus development Source: Ensembl
Neutrophil degranulation Source: UniProtKB
Phagocytosis Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of DNA metabolic process Source: Ensembl
Positive regulation of endothelial cell migration Source: UniProtKB
Response to glucocorticoid Source: Ensembl
Response to growth factor Source: Ensembl
Cellular Location
Extracellular exosome; Plasma membrane; Axon; Cytoplasm; Dendrite; Membrane; Neuronal cell body; Phagocytic vesicle membrane; Specific granule

Zhang, Z., Li, Z., Ma, Z., Deng, M., Xing, M., Wu, J., ... & Zou, W. (2021). Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats. Neural Plasticity, 2021.

Xu, B., Zhang, X., Gao, Y., Song, J., & Shi, B. (2021). Microglial Annexin A3 promoted the development of melanoma via activation of hypoxia‐inducible factor‐1α/vascular endothelial growth factor signaling pathway. Journal of Clinical Laboratory Analysis, 35(2), e23622.

Toufiq, M., Roelands, J., Alfaki, M., Syed Ahamed Kabeer, B., Saadaoui, M., Lakshmanan, A. P., ... & Garand, M. (2020). Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data. Immunology, 161(4), 291-302.

Huang, K., Crist, A. M., Patel, N. R., Blanks, A., Carter, K., Cleaver, O., & Meadows, S. M. (2020). Annexin A3 is necessary for parallel artery‐vein alignment in the mouse retina. Developmental Dynamics, 249(5), 666-678.

Zeng, X., Wang, S., Gui, P., Wu, H., & Li, Z. (2019). Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS. Molecular medicine reports, 20(3), 2583-2590.

Xu, R., Yin, J., Zhang, Y., & Zhang, S. (2019). Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway. Journal of cellular biochemistry, 120(9), 14585-14593.

Meng, H., Zhang, Y., An, S. T., & Chen, Y. (2019). Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction. Journal of cellular physiology, 234(7), 10535-10546.

Du, R., Liu, B., Zhou, L., Wang, D., He, X., Xu, X., ... & Liu, S. (2018). Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell death & disease, 9(2), 1-11.

Tong, M., Che, N., Zhou, L., Luk, S. T., Kau, P. W., Chai, S., ... & Ma, S. (2018). Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. Journal of hepatology, 69(4), 826-839.

Ma, X. L., Jiang, M., Zhao, Y., Wang, B. L., Shen, M. N., Zhou, Y., ... & Guo, W. (2018). Application of serum annexin A3 in diagnosis, outcome prediction and therapeutic response evaluation for patients with hepatocellular carcinoma. Annals of surgical oncology, 25(6), 1686-1694.

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For research use only. Not intended for any clinical use.

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