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Mouse Anti-ASGR1 Recombinant Antibody (CBYC-A820) (CBMAB-A3765-YC)

Provided herein is a Mouse monoclonal antibody against Human Asialoglycoprotein Receptor 1. The antibody can be used for immunoassay techniques, such as IA, ICC, IF, IHC-Fr, WB.
See all ASGR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A820
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
A synthetic peptide corresponding to human ASGR1.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Asialoglycoprotein Receptor 1
Introduction
ASGR1 is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal gala
Entrez Gene ID
Human432
Rat11889
UniProt ID
HumanP07306
RatP02706
Alternative Names
HL-1; ASGPR; ASGPR1; CLEC4H1
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW
Cellular Location
Isoform H1a: Membrane
Isoform H1b: Secreted
Topology
Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa
PTM
Phosphorylated on a cytoplasmic Ser residue.

Susan-Resiga, D., Girard, E., Essalmani, R., Roubtsova, A., Marcinkiewicz, J., Derbali, M. R., ... & Seidah, N. G. (2021). Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin. bioRxiv.

Zhao, X., Tang, B., Shi, Z. H., Deng, Z. W., Deng, Y., Tan, L. M., ... & Qiu, C. F. (2020). Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels. Chinese medical journal, 133(12), 1505.

Janiszewski, M., Sohn, W., Su, C., Hsu, Y. H., Finger, E., & Kaufman, A. (2019). A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, ASCENDING SINGLE-DOSE, PHASE 1 STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF AMG 529, A NOVEL ANTI-ASGR1 MONOCLONAL ANTIBODY, IN HEALTHY SUBJECTS. Journal of the American College of Cardiology, 73(9S1), 1755-1755.

Tanowitz, M., Hettrick, L., Revenko, A., Kinberger, G. A., Prakash, T. P., & Seth, P. P. (2017). Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes. Nucleic acids research, 45(21), 12388-12400.

Chen, C., Li, K., Jiang, H., Song, F., Gao, H., Pan, X., ... & Li, Z. (2017). Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 66(4), 475-489.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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