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ASGR1

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Full Name
Asialoglycoprotein Receptor 1
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW
Cellular Location
Isoform H1a: Membrane
Isoform H1b: Secreted
Topology
Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa
PTM
Phosphorylated on a cytoplasmic Ser residue.
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Anti-ASGR1 antibodies

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Mouse Anti-ASGR1 Recombinant Antibody (CBYC-A821) (CBMAB-A3766-YC)

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Target: ASGR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-A821
Application*: E, WB
Datasheet SDS

Rat Anti-ASGR1 Recombinant Antibody (CBFYA-0207) (CBMAB-X0292-FY)

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Target: ASGR1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0207
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-ASGR1 Recombinant Antibody (CBCNC-117) (CBMAB-C1078-CN)

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Target: ASGR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-117
Application*: P
Datasheet SDS

Mouse Anti-ASGR1 Recombinant Antibody (CBYC-A820) (CBMAB-A3765-YC)

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Target: ASGR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-A820
Application*: E, WB
Datasheet SDS

Rabbit Anti-ASGR1 Recombinant Antibody (CBYC-A819) (CBMAB-A3764-YC)

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Target: ASGR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-A819
Application*: P
Datasheet SDS

Mouse Anti-ASGR1 Recombinant Antibody (A5) (CBMAB-A3763-YC)

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Target: ASGR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A5
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ASGR1 Recombinant Antibody (8D7) (CBMAB-A3761-YC)

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Target: ASGR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8D7
Application*: WB, IP, IF, FC
Datasheet SDS

Rabbit Anti-ASGR1 Recombinant Antibody (CBHb383) (CBMAB-Hb042-LY)

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Target: ASGR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBHb383
Application*: WB, IP, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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