ASGR1

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Asialoglycoprotein Receptor 1

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW

Isoform H1a: Membrane
Isoform H1b: Secreted

Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa

Phosphorylated on a cytoplasmic Ser residue.