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Mouse Anti-ASGR1 Recombinant Antibody (CBCNC-117) (CBMAB-C1078-CN)

This product is a Mouse antibody that recognizes ASGR1. The antibody CBCNC-117 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all ASGR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-117
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Recombinant Human ASGPR1 protein.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1:20-1:80

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent

Target

Full Name
Asialoglycoprotein Receptor 1
Introduction
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
432
UniProt ID
P07306
Alternative Names
Asialoglycoprotein Receptor 1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; CLEC4H1; HL-1; ASGP-R 1; ASGPR 1; ASGPR1; ASGPR;
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW
Cellular Location
Isoform H1a: Membrane
Isoform H1b: Secreted
Topology
Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa
PTM
Phosphorylated on a cytoplasmic Ser residue.

Susan-Resiga, D., Girard, E., Essalmani, R., Roubtsova, A., Marcinkiewicz, J., Derbali, M. R., ... & Seidah, N. G. (2021). Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin. bioRxiv.

Zhao, X., Tang, B., Shi, Z. H., Deng, Z. W., Deng, Y., Tan, L. M., ... & Qiu, C. F. (2020). Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels. Chinese medical journal, 133(12), 1505.

Janiszewski, M., Sohn, W., Su, C., Hsu, Y. H., Finger, E., & Kaufman, A. (2019). A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, ASCENDING SINGLE-DOSE, PHASE 1 STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF AMG 529, A NOVEL ANTI-ASGR1 MONOCLONAL ANTIBODY, IN HEALTHY SUBJECTS. Journal of the American College of Cardiology, 73(9S1), 1755-1755.

Tanowitz, M., Hettrick, L., Revenko, A., Kinberger, G. A., Prakash, T. P., & Seth, P. P. (2017). Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes. Nucleic acids research, 45(21), 12388-12400.

Chen, C., Li, K., Jiang, H., Song, F., Gao, H., Pan, X., ... & Li, Z. (2017). Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 66(4), 475-489.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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