Mouse Anti-ASGR1 Recombinant Antibody (CBCNC-117) (CBMAB-C1078-CN)

Name: Mouse Anti-ASGR1 Recombinant Antibody (CBCNC-117)
SKU: CBMAB-C1078-CN
Rating: 5 (1 reviews)

See all ASGR1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-117

Application

IHC-P

Immunogen

Recombinant Human ASGPR1 protein.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC-P	1:20-1:80

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

More Infomation

Target

Full Name

Asialoglycoprotein Receptor 1

Introduction

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Entrez Gene ID

432

UniProt ID

P07306

Alternative Names

Asialoglycoprotein Receptor 1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; CLEC4H1; HL-1; ASGP-R 1; ASGPR 1; ASGPR1; ASGPR;

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Biological Process

Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW

Cellular Location

Isoform H1a: Membrane
Isoform H1b: Secreted

Topology

Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa

PTM

Phosphorylated on a cytoplasmic Ser residue.

Susan-Resiga, D., Girard, E., Essalmani, R., Roubtsova, A., Marcinkiewicz, J., Derbali, M. R., ... & Seidah, N. G. (2021). Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin. bioRxiv.

Zhao, X., Tang, B., Shi, Z. H., Deng, Z. W., Deng, Y., Tan, L. M., ... & Qiu, C. F. (2020). Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels. Chinese medical journal, 133(12), 1505.

Janiszewski, M., Sohn, W., Su, C., Hsu, Y. H., Finger, E., & Kaufman, A. (2019). A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, ASCENDING SINGLE-DOSE, PHASE 1 STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF AMG 529, A NOVEL ANTI-ASGR1 MONOCLONAL ANTIBODY, IN HEALTHY SUBJECTS. Journal of the American College of Cardiology, 73(9S1), 1755-1755.

Tanowitz, M., Hettrick, L., Revenko, A., Kinberger, G. A., Prakash, T. P., & Seth, P. P. (2017). Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes. Nucleic acids research, 45(21), 12388-12400.

Chen, C., Li, K., Jiang, H., Song, F., Gao, H., Pan, X., ... & Li, Z. (2017). Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 66(4), 475-489.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-ASGR1 Recombinant Antibody (CBCNC-117)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-ASGR1 Recombinant Antibody (CBYC-A819) (CAT#: CBMAB-A3764-YC)

Mouse Anti-ASGR1 Recombinant Antibody (8D7) (CAT#: CBMAB-A3761-YC)

Mouse Anti-ASGR1 Recombinant Antibody (CBYC-A820) (CAT#: CBMAB-A3765-YC)

Rat Anti-ASGR1 Recombinant Antibody (CBFYA-0207) (CAT#: CBMAB-X0292-FY)

Mouse Anti-ASGR1 Recombinant Antibody (CBYC-A821) (CAT#: CBMAB-A3766-YC)

Mouse Anti-ASGR1 Recombinant Antibody (A5) (CAT#: CBMAB-A3763-YC)

Rabbit Anti-ASGR1 Recombinant Antibody (CBHb383) (CAT#: CBMAB-Hb042-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry