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Rat Anti-ASGR1 Recombinant Antibody (CBFYA-0207) (CBMAB-X0292-FY)

This product is mouse antibody that recognizes ASGPR1. The antibody CBFYA-0207 can be used for immunoassay techniques such as: FC, IHC-Fr, Immunoassay, IF, WB.
See all ASGR1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYA-0207
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse ASGR1/ASGPR1 Ser60-Asn284.
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5 µg/ml
IHC5-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Asialoglycoprotein Receptor 1
Introduction
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues.
Entrez Gene ID
Human432
Rat11889
UniProt ID
HumanP07306
RatP02706
Alternative Names
HL-1; ASGPR; ASGPR1; CLEC4H1
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Cellular response to extracellular stimulus Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Receptor-mediated endocytosis Source: ProtInc
Viral process Source: UniProtKB-KW
Cellular Location
Isoform H1a: Membrane
Isoform H1b: Secreted
Topology
Cytoplasmic: 1-40 aa
Helical: 41-61 aa
Extracellular: 62-291 aa
PTM
Phosphorylated on a cytoplasmic Ser residue.

Susan-Resiga, D., Girard, E., Essalmani, R., Roubtsova, A., Marcinkiewicz, J., Derbali, M. R., ... & Seidah, N. G. (2021). Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin. bioRxiv.

Zhao, X., Tang, B., Shi, Z. H., Deng, Z. W., Deng, Y., Tan, L. M., ... & Qiu, C. F. (2020). Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels. Chinese medical journal, 133(12), 1505.

Janiszewski, M., Sohn, W., Su, C., Hsu, Y. H., Finger, E., & Kaufman, A. (2019). A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, ASCENDING SINGLE-DOSE, PHASE 1 STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF AMG 529, A NOVEL ANTI-ASGR1 MONOCLONAL ANTIBODY, IN HEALTHY SUBJECTS. Journal of the American College of Cardiology, 73(9S1), 1755-1755.

Tanowitz, M., Hettrick, L., Revenko, A., Kinberger, G. A., Prakash, T. P., & Seth, P. P. (2017). Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes. Nucleic acids research, 45(21), 12388-12400.

Chen, C., Li, K., Jiang, H., Song, F., Gao, H., Pan, X., ... & Li, Z. (2017). Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 66(4), 475-489.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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