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Rabbit Anti-ATP1B1 Recombinant Antibody (24) (CBMAB-0107-CN)

This product is a mouse antibody that recognizes ATP1B1 of chicken. The antibody 24 can be used for immunoassay techniques such as: BL, IHC, IP, WB.
See all ATP1B1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat, Mouse
Clone
24
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 204-303 of human Sodium Potassium ATPase Beta 1.
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase Na+/K+ Transporting Subunit Beta 1
Introduction
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Entrez Gene ID
396529
UniProt ID
P08251
Alternative Names
ATP1B
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Biological Process
ATP metabolic process Source: BHF-UCL
Cardiac muscle contraction Source: BHF-UCL
Cation transmembrane transport Source: ARUK-UCL
Cell adhesion Source: UniProtKB-KW
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Establishment or maintenance of transmembrane electrochemical gradient Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of calcium:sodium antiporter activity Source: BHF-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of P-type sodium:potassium-exchanging transporter activity Source: ARUK-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: ARUK-UCL
Protein localization to plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Protein transport into plasma membrane raft Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
Regulation of gene expression Source: BHF-UCL
Relaxation of cardiac muscle Source: BHF-UCL
Response to hypoxia Source: Ensembl
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL
Cellular Location
Cell membrane; Apical cell membrane. Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Topology
Cytoplasmic: 1-34 aa
Helical: 35-62 aa
Extracellular: 63-303 aa
PTM
Glutathionylated (By similarity). N-glycosylated (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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