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Mouse Anti-ATP1B1 Recombinant Antibody (464.8) (CBMAB-1165-CN)

This product is a mouse antibody that recognizes ATP1B1 of rabbit. The antibody 464.8 can be used for immunoassay techniques such as: FC, WB.
See all ATP1B1 antibodies
Published Data
Fig.1 Cell surface expression and association of VGSC α and β1 or β1B subunits.
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Fig.2 β1B is detected in the ER in the absence of Nav1.5, and at the cell surface when coexpressed with Nav1.5.
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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle, Dog, Human, Pig
Clone
464.8
Antibody Isotype
IgG2a, κ
Application
IF, IP, WB

Basic Information

Immunogen
Na+/K+-ATPase β1 from rabbit renal outer medulla.
Specificity
Mouse, Rat, Cattle, Dog, Human, Pig
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase Na+/K+ Transporting Subunit Beta 1
Introduction
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Entrez Gene ID
Human481
Rat25650
Dog403966
Cattle519758
Rabbit100008749
Pig396898
UniProt ID
HumanP05026
RatP07340
DogF1PMF0
CattleG3MWR4
RabbitQ9TT37
PigP05027
Alternative Names
sodium/potassium-transporting ATPase subunit beta-1; ATPase, Na+/K+ transporting, beta 1 polypeptide; Na+,K+-ATPase beta 1 subunit; sodium/potassium-dependent ATPase subunit beta-1; EC 3.6.1.3
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Biological Process
ATP metabolic process Source: BHF-UCL
Cardiac muscle contraction Source: BHF-UCL
Cation transmembrane transport Source: ARUK-UCL
Cell adhesion Source: UniProtKB-KW
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Establishment or maintenance of transmembrane electrochemical gradient Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of calcium:sodium antiporter activity Source: BHF-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of P-type sodium:potassium-exchanging transporter activity Source: ARUK-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: ARUK-UCL
Protein localization to plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Protein transport into plasma membrane raft Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
Regulation of gene expression Source: BHF-UCL
Relaxation of cardiac muscle Source: BHF-UCL
Response to hypoxia Source: Ensembl
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL
Cellular Location
Cell membrane; Apical cell membrane. Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Topology
Cytoplasmic: 1-34 aa
Helical: 35-62 aa
Extracellular: 63-303 aa
PTM
Glutathionylated (By similarity). N-glycosylated (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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