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Rabbit Anti-ATP2A1 Recombinant Antibody (CBXS-1569) (CBMAB-S4418-CQ)

This product is a rabbit antibody that recognizes ATP2A1. The antibody CBXS-1569 can be used for immunoassay techniques such as: WB.
See all ATP2A1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1569
Antibody Isotype
IgG
Application
IHC, IP, WB

Basic Information

Immunogen
A synthesized peptide derived from human SERCA1 ATPase.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:5,000
IP1:50
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1
Introduction
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Entrez Gene ID
Human487
Mouse11937
Rat116601
UniProt ID
HumanO14983
MouseQ8R429
RatQ64578
Alternative Names
ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1; Calcium Pump 1; Calcium-Transporting ATPase Sarcoplasmic Reticulum Type, Fast Twitch Skeletal Muscle Isoform; ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1; Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1; Endoplasmic Reticulum Class 1/2 Ca(2+) ATPase;
Function
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity).
Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).
Biological Process
Apoptotic mitochondrial changes Source: BHF-UCL
Calcium ion import Source: BHF-UCL
Calcium ion import into sarcoplasmic reticulum Source: UniProtKB
Calcium ion transmembrane transport Source: GO_Central
Calcium ion transport Source: UniProtKB
Cellular calcium ion homeostasis Source: GO_Central
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Maintenance of mitochondrion location Source: BHF-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: BHF-UCL
Negative regulation of striated muscle contraction Source: UniProtKB
Positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: UniProtKB
Positive regulation of calcium ion import into sarcoplasmic reticulum Source: UniProtKB
Positive regulation of cardiac muscle cell contraction Source: UniProtKB
Positive regulation of endoplasmic reticulum calcium ion concentration Source: BHF-UCL
Positive regulation of fast-twitch skeletal muscle fiber contraction Source: UniProtKB
Positive regulation of mitochondrial calcium ion concentration Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Regulation of striated muscle contraction Source: UniProtKB
Relaxation of skeletal muscle Source: BHF-UCL
Response to endoplasmic reticulum stress Source: BHF-UCL
Cellular Location
Endoplasmic reticulum membrane; Sarcoplasmic reticulum membrane
Involvement in disease
Brody myopathy (BRM): A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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