ATP2A1

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Full Name
ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1
Function
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity).
Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).
Biological Process
Apoptotic mitochondrial changes Source: BHF-UCL
Calcium ion import Source: BHF-UCL
Calcium ion import into sarcoplasmic reticulum Source: UniProtKB
Calcium ion transmembrane transport Source: GO_Central
Calcium ion transport Source: UniProtKB
Cellular calcium ion homeostasis Source: GO_Central
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Maintenance of mitochondrion location Source: BHF-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: BHF-UCL
Negative regulation of striated muscle contraction Source: UniProtKB
Positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: UniProtKB
Positive regulation of calcium ion import into sarcoplasmic reticulum Source: UniProtKB
Positive regulation of cardiac muscle cell contraction Source: UniProtKB
Positive regulation of endoplasmic reticulum calcium ion concentration Source: BHF-UCL
Positive regulation of fast-twitch skeletal muscle fiber contraction Source: UniProtKB
Positive regulation of mitochondrial calcium ion concentration Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Regulation of striated muscle contraction Source: UniProtKB
Relaxation of skeletal muscle Source: BHF-UCL
Response to endoplasmic reticulum stress Source: BHF-UCL
Cellular Location
Endoplasmic reticulum membrane; Sarcoplasmic reticulum membrane
Involvement in disease
Brody myopathy (BRM): A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation.
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Anti-ATP2A1 antibodies

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Mouse Anti-ATP2A1 Recombinant Antibody (IIH11) (CBMAB-S6370-CQ)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Dog, Rat, Guinea pig, Rabbit
Clone: IIH11
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBXS-3306) (CBMAB-S6045-CQ)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat, Human, Rabbit, Dog
Clone: CBXS-3306
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBXS-2862) (CBMAB-S5612-CQ)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2862
Application*: WB, E
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBXS-2685) (CBMAB-S5437-CQ)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat, Human
Clone: CBXS-2685
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBXS-2031) (CBMAB-S4798-CQ)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Mouse, Rat, Human
Clone: CBXS-2031
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-ATP2A1 Recombinant Antibody (CBXS-1569) (CBMAB-S4418-CQ)

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Target: ATP2A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1569
Application*: IH, IP, WB
Datasheet SDS

Rabbit Anti-ATP2A1 Recombinant Antibody (CBXS-1568) (CBMAB-S4417-CQ)

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Target: ATP2A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1568
Application*: WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (VE121G9) (CBMAB-A4027-YC)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Amphibian, Dog, Human, Mouse, Pig, Rabbit, Rat, Yeast
Clone: VE121G9
Application*: IC, WB, IF, IH, IP
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (4B8) (CBMAB-A4026-YC)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4B8
Application*: P, WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (1B11) (CBMAB-A4025-YC)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B11
Application*: E, IC, IF, P, WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBT2256) (V2LY-0625-LY696)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT2256
Application*: WB
Datasheet SDS

Mouse Anti-ATP2A1 Recombinant Antibody (CBT4349) (V2LY-0625-LY694)

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Target: ATP2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT4349
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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