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Mouse Anti-BACH1 Recombinant Antibody (1B8) (CBMAB-A0695-LY)

The product is antibody recognizes BACH1. The antibody 1B8 immunoassay techniques such as: WB, ELISA.
See all BACH1 antibodies
Published Data
Fig. 1 Western blot analysis of cytoplasmic (cyto) protein samples for Bach1 and b-actin (ACTB).
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Fig. 2 Fluorescent images of DAPI, Alexa Fluor 488, and their merged images.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
1B8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
BACH1 (NP_996749, 396 a.a. ~ 492 a.a) partial recombinant protein with GST tag.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BACH1
Introduction
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
Human571
Mouse12013
UniProt ID
HumanO14867
MouseP97302
Function
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity).
Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
Biological Process
DNA repair Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
Regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
Cellular Location
Nucleus
PTM
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.

Liu, S., Duan, K., Zhang, X., Cao, X., Wang, X., Meng, F., ... & Wang, X. (2021). Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression. Aging (Albany NY), 13(13), 17274.

Tsuneyoshi, T. (2020). BACH1 mediates the antioxidant properties of aged garlic extract. Experimental and therapeutic medicine, 19(2), 1500-1503.

Zhao, F., Ma, B., Lv, Z., Chen, J., Cai, Y., Xu, C., & Cai, Y. (2020). Zerumbone decreases BACH1 levels by upregulating miR-708 to inhibit breast cancer cell proliferation and invasion. Tropical Journal of Pharmaceutical Research, 19(7), 1411-1416.

Nishizawa, H., Matsumoto, M., Shindo, T., Saigusa, D., Kato, H., Suzuki, K., ... & Igarashi, K. (2020). Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. Journal of Biological Chemistry, 295(1), 69-82.

Kim, E. N., Gao, M., Choi, H., & Jeong, G. S. (2020). Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation. Molecules, 25(3), 656.

Sun, X., Qian, Y., Wang, X., Cao, R., Zhang, J., Chen, W., & Fang, M. (2020). LncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1. Cancer cell international, 20(1), 1-11.

Patsalos, A., Tzerpos, P., Halasz, L., Nagy, G., Giannakis, N., Pap, A., ... & Nagy, L. (2019). Macrophage BACH1, a heme regulated transcriptional repressor, controls HMOX1 and skeletal muscle regeneration. The FASEB Journal, 33(S1), 868-20.

Tsuneyoshi, T., Kunimura, K., & Morihara, N. (2019). S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide, 84, 22-29.

Zhu, G. D., Liu, F., OuYang, S., Zhou, R., Jiang, F. N., Zhang, B., & Liao, W. J. (2018). BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway. Biochemical and biophysical research communications, 499(2), 120-127.

Zhang, H., Qian, H., Tao, B., Yang, M., Gong, J., Yi, H., & Tang, S. (2018). The association between BACH1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort. Infection, Genetics and Evolution, 66, 217-221.

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For research use only. Not intended for any clinical use.

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