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Rabbit Anti-BACH1 Recombinant Antibody (E4E7B) (CBMAB-CP0029-LY)

The product is antibody recognizes BACH1. The antibody immunoassay techniques such as: WB.
See all BACH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
E4E7B
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Recombinant protein specific to the central region of human BACH1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BACH1
Introduction
BACH1-AS1 (BACH1 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.
Entrez Gene ID
571
UniProt ID
O14867
Alternative Names
BTB Domain And CNC Homolog 1; BTB And CNC Homology 1; Basic Leucine Zipper Transcription Factor 1; Basic Region Leucine Zipper Transcriptional Regulator BACH1; Transcription Regulator Protein BACH1; BTB And CNC Homolog 1; BACH-1; BTBD24; HA2303;
Function
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity).
Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
Biological Process
DNA repair Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
Regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
Cellular Location
Nucleus
PTM
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.

Liu, S., Duan, K., Zhang, X., Cao, X., Wang, X., Meng, F., ... & Wang, X. (2021). Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression. Aging (Albany NY), 13(13), 17274.

Tsuneyoshi, T. (2020). BACH1 mediates the antioxidant properties of aged garlic extract. Experimental and therapeutic medicine, 19(2), 1500-1503.

Zhao, F., Ma, B., Lv, Z., Chen, J., Cai, Y., Xu, C., & Cai, Y. (2020). Zerumbone decreases BACH1 levels by upregulating miR-708 to inhibit breast cancer cell proliferation and invasion. Tropical Journal of Pharmaceutical Research, 19(7), 1411-1416.

Nishizawa, H., Matsumoto, M., Shindo, T., Saigusa, D., Kato, H., Suzuki, K., ... & Igarashi, K. (2020). Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. Journal of Biological Chemistry, 295(1), 69-82.

Kim, E. N., Gao, M., Choi, H., & Jeong, G. S. (2020). Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation. Molecules, 25(3), 656.

Sun, X., Qian, Y., Wang, X., Cao, R., Zhang, J., Chen, W., & Fang, M. (2020). LncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1. Cancer cell international, 20(1), 1-11.

Patsalos, A., Tzerpos, P., Halasz, L., Nagy, G., Giannakis, N., Pap, A., ... & Nagy, L. (2019). Macrophage BACH1, a heme regulated transcriptional repressor, controls HMOX1 and skeletal muscle regeneration. The FASEB Journal, 33(S1), 868-20.

Tsuneyoshi, T., Kunimura, K., & Morihara, N. (2019). S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide, 84, 22-29.

Zhu, G. D., Liu, F., OuYang, S., Zhou, R., Jiang, F. N., Zhang, B., & Liao, W. J. (2018). BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway. Biochemical and biophysical research communications, 499(2), 120-127.

Zhang, H., Qian, H., Tao, B., Yang, M., Gong, J., Yi, H., & Tang, S. (2018). The association between BACH1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort. Infection, Genetics and Evolution, 66, 217-221.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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