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Rabbit Anti-BAG2 Recombinant Antibody (CBYY-0162) (CBMAB-0163-YY)

This product is rabbit antibody that recognizes BAG2. The antibody CBYY-0162 can be used for immunoassay techniques such as: WB, IP, IHC-P, ICC, FC
See all BAG2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-0162
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Immunogen
Recombinant protein within Human BAG2 aa 1-118.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH 7.4, 0.05% BSA, 40% glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2-associated athanogene 2
Introduction
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Entrez Gene ID
9532
UniProt ID
O95816
Alternative Names
BCL2 Associated Athanogene 2; Bcl-2-Associated Athanogene 2; BAG-2; DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2); BAG Family Molecular Chaperone Regulator 2; DJ417I1.2;
Function
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
Biological Process
Negative regulation of protein binding Source: ARUK-UCL
Negative regulation of protein ubiquitination Source: ARUK-UCL
Negative regulation of ubiquitin protein ligase activity Source: ARUK-UCL
Positive regulation of proteasomal protein catabolic process Source: ARUK-UCL
Positive regulation of protein processing Source: ARUK-UCL
Protein folding Source: ProtInc
Protein metabolic process Source: MGI
Protein stabilization Source: ARUK-UCL
Regulation of cellular response to heat Source: Reactome
Cellular Location
Dendritic microtubule; Cytosol, Axon; Chaperone complex; Dendrite
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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