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BAG2

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]

Full Name

BCL2-associated athanogene 2

Function

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).

Biological Process

Negative regulation of protein binding Source: ARUK-UCL
Negative regulation of protein ubiquitination Source: ARUK-UCL
Negative regulation of ubiquitin protein ligase activity Source: ARUK-UCL
Positive regulation of proteasomal protein catabolic process Source: ARUK-UCL
Positive regulation of protein processing Source: ARUK-UCL
Protein folding Source: ProtInc
Protein metabolic process Source: MGI
Protein stabilization Source: ARUK-UCL
Regulation of cellular response to heat Source: Reactome

Cellular Location

Dendritic microtubule; Cytosol, Axon; Chaperone complex; Dendrite

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Anti-BAG2 antibodies

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Mouse Anti-BAG2 Recombinant Antibody (CBYY-1814) (CBMAB-2163-YY)

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Target: BAG2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-1814

Application*: WB, IP, IF, E

Mouse Anti-BAG2 Recombinant Antibody (CBYY-1797) (CBMAB-2146-YY)

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Target: BAG2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-1797

Application*: WB, IP, IF, E

Rabbit Anti-BAG2 Recombinant Antibody (CBYY-0163) (CBMAB-0164-YY)

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Target: BAG2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-0163

Application*: WB, IP, IH, IF, FC

Rabbit Anti-BAG2 Recombinant Antibody (CBYY-0162) (CBMAB-0163-YY)

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Target: BAG2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-0162

Application*: WB, FC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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