Rabbit Anti-BCL2A1 Recombinant Antibody (CBYY-0397) (CBMAB-0399-YY)

Name: Rabbit Anti-BCL2A1 Recombinant Antibody (CBYY-0397)
SKU: CBMAB-0399-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYY-0397

Application

WB, IHC-P, FC

Immunogen

Synthetic peptide within Human BCL2A1 aa 2-48.

Host Species

Rabbit

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IHC-P	1:50-1:200
FC	1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

TBS, pH 7.4, 40% Glycerol, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BCL2 Related Protein A1

Introduction

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorBovinel ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforMouse have been found for this gene.

Entrez Gene ID

Human	597
Mouse	12043
Rat	12044

UniProt ID

Human	Q16548
Mouse	Q07440
Rat	Q925A9

Alternative Names

BCL2 Related Protein A1; Hemopoietic-Specific Early Response Protein; Bcl-2-Like Protein 5; Protein BFL-1; Bcl2-L-5; BCL2L5; HBPA1; BFL1; GRS;

Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).

Biological Process

Aging Source: Ensembl
Cerebral cortex development Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB

Cellular Location

Cytoplasm

Chilakamarti, R. (2021). Lung Epithelial Regulation of BCL2 Related Protein A1 (BCL2A1) by Coronaviruses (SARS-CoV) and Type I Interferon Signaling. bioRxiv.

Liu, F., Pan, R., Ding, H., Gu, L., Yang, Y., Li, C., ... & Nie, Y. (2021). UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Molecular Oncology.

Li, X., Dou, J., You, Q., & Jiang, Z. (2021). Inhibitors of BCL2A1/Bfl-1 Protein: Potential Stock in Cancer Therapy. European Journal of Medicinal Chemistry, 113539.

Zheng, Q., Gan, G., Gao, X., Luo, Q., & Chen, F. (2021). Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma. OncoTargets and therapy, 14, 1673.

Lin, P., Li, J., Ye, F., Fu, W., Hu, X., Shao, Z., & Song, C. (2020). KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. American journal of cancer research, 10(10), 3302.

Kim, J. T., Cho, H. J., Cho, M. Y., Lim, J., Park, E. S., Lim, J. S., & Lee, H. G. (2019). Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis. Biochemical and biophysical research communications, 513(4), 940-946.

Hiraki, M., Maeda, T., Mehrotra, N., Jin, C., Alam, M., Bouillez, A., ... & Kufe, D. (2018). Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer. Signal transduction and targeted therapy, 3(1), 1-8.

Sochalska, M., Schuler, F., Weiss, J. G., Prchal-Murphy, M., Sexl, V., & Villunger, A. (2017). MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis. Oncogene, 36(15), 2066-2073.

Berberich, I., & Hildeman, D. A. (2017). The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1. Cell death and differentiation, 24(4), 572.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-BCL2A1 Recombinant Antibody (CBYY-0398) (CAT#: CBMAB-0400-YY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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