Human BCL2A1 ELISA Kit (V2LY-0626-LY5506)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0094 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
20.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
BCL2 Related Protein A1
Function
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).
Biological Process
Aging Source: Ensembl
Cerebral cortex development Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Cellular Location
Cytoplasm

Chilakamarti, R. (2021). Lung Epithelial Regulation of BCL2 Related Protein A1 (BCL2A1) by Coronaviruses (SARS-CoV) and Type I Interferon Signaling. bioRxiv.

Liu, F., Pan, R., Ding, H., Gu, L., Yang, Y., Li, C., ... & Nie, Y. (2021). UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Molecular Oncology.

Li, X., Dou, J., You, Q., & Jiang, Z. (2021). Inhibitors of BCL2A1/Bfl-1 Protein: Potential Stock in Cancer Therapy. European Journal of Medicinal Chemistry, 113539.

Zheng, Q., Gan, G., Gao, X., Luo, Q., & Chen, F. (2021). Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma. OncoTargets and therapy, 14, 1673.

Lin, P., Li, J., Ye, F., Fu, W., Hu, X., Shao, Z., & Song, C. (2020). KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. American journal of cancer research, 10(10), 3302.

Kim, J. T., Cho, H. J., Cho, M. Y., Lim, J., Park, E. S., Lim, J. S., & Lee, H. G. (2019). Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis. Biochemical and biophysical research communications, 513(4), 940-946.

Hiraki, M., Maeda, T., Mehrotra, N., Jin, C., Alam, M., Bouillez, A., ... & Kufe, D. (2018). Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer. Signal transduction and targeted therapy, 3(1), 1-8.

Sochalska, M., Schuler, F., Weiss, J. G., Prchal-Murphy, M., Sexl, V., & Villunger, A. (2017). MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis. Oncogene, 36(15), 2066-2073.

Berberich, I., & Hildeman, D. A. (2017). The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1. Cell death and differentiation, 24(4), 572.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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