Human Recombinant BCL2A1 protein, His Tag (V2LY-0526-LY2312)

Name: Human Recombinant BCL2A1 protein, His Tag
SKU: V2LY-0526-LY2312
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant BCL2A1 protein, His Tag consist of Amino Acid: 1-152 and predicts a molecular mass of 19.7 kDa.

Molecule Mass

19.7 kDa

Sequence

Amino Acid: 1-152

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

BCL2 Related Protein A1

Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).

Biological Process

Aging Source: Ensembl
Cerebral cortex development Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB

Cellular Location

Cytoplasm

Chilakamarti, R. (2021). Lung Epithelial Regulation of BCL2 Related Protein A1 (BCL2A1) by Coronaviruses (SARS-CoV) and Type I Interferon Signaling. bioRxiv.

Liu, F., Pan, R., Ding, H., Gu, L., Yang, Y., Li, C., ... & Nie, Y. (2021). UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Molecular Oncology.

Li, X., Dou, J., You, Q., & Jiang, Z. (2021). Inhibitors of BCL2A1/Bfl-1 Protein: Potential Stock in Cancer Therapy. European Journal of Medicinal Chemistry, 113539.

Zheng, Q., Gan, G., Gao, X., Luo, Q., & Chen, F. (2021). Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma. OncoTargets and therapy, 14, 1673.

Lin, P., Li, J., Ye, F., Fu, W., Hu, X., Shao, Z., & Song, C. (2020). KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. American journal of cancer research, 10(10), 3302.

Kim, J. T., Cho, H. J., Cho, M. Y., Lim, J., Park, E. S., Lim, J. S., & Lee, H. G. (2019). Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis. Biochemical and biophysical research communications, 513(4), 940-946.

Hiraki, M., Maeda, T., Mehrotra, N., Jin, C., Alam, M., Bouillez, A., ... & Kufe, D. (2018). Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer. Signal transduction and targeted therapy, 3(1), 1-8.

Sochalska, M., Schuler, F., Weiss, J. G., Prchal-Murphy, M., Sexl, V., & Villunger, A. (2017). MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis. Oncogene, 36(15), 2066-2073.

Berberich, I., & Hildeman, D. A. (2017). The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1. Cell death and differentiation, 24(4), 572.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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