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Mouse Anti-BLVRA Recombinant Antibody (CBYY-0628) (CBMAB-0631-YY)

This product is mouse antibody that recognizes BLVRA. The antibody CBYY-0628 can be used for immunoassay techniques such as: ELISA, IP, WB
See all BLVRA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0628
Antibody Isotype
IgG2a, κ
Application
WB, E, IP

Basic Information

Immunogen
Recombinant BLVRA of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-Terminus

Target

Full Name
biliverdin reductase A
Introduction
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
644
UniProt ID
P53004
Alternative Names
Biliverdin Reductase A; Biliverdin-IX Alpha-Reductase; BVR A; BLVR; BVR; Testis Tissue Sperm-Binding Protein Li 61n; EC 1.3.1.24; BVRA;
Function
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
Biological Process
Heme catabolic process Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Hyperbiliverdinemia (HBLVD): A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis.

Stec, D. E., Gordon, D. M., Nestor-Kalinoski, A. L., Donald, M. C., Mitchell, Z. L., Creeden, J. F., & Hinds, T. D. (2020). Biliverdin reductase A (BVRA) knockout in adipocytes induces hypertrophy and reduces mitochondria in white fat of obese mice. Biomolecules, 10(3), 387.

Kim, S. J., Shin, M. J., Kim, D. W., Yeo, H. J., Yeo, E. J., Choi, Y. J., ... & Choi, S. Y. (2020). Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling. International journal of molecular sciences, 21(8), 2672.

Mao, H., Xu, Y., Zhang, Z., Sun, G., Wang, Z., Qiao, D., ... & Bo, P. (2020). Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway. Cancer Management and Research, 12, 2697.

Kobachi, K., Kuno, S., Sato, S., Sumiyama, K., Matsuda, M., & Terai, K. (2020). Biliverdin reductase-A deficiency brighten and sensitize biliverdin-binding chromoproteins. Cell Structure and Function, 20010.

Gordon, D. M., Adeosun, S. O., Ngwudike, S. I., Anderson, C. D., Hall, J. E., Hinds Jr, T. D., & Stec, D. E. (2019). CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation. Archives of biochemistry and biophysics, 672, 108072.

Zhang, Y., Ding, Y., Lu, T., Zhang, Y., Xu, N., McBride, D. W., ... & Zhang, J. H. (2018). Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway. Journal of neuroinflammation, 15(1), 1-12.

Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds Jr, T. D., & Stec, D. E. (2018). Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells. American Journal of Physiology-Renal Physiology, 315(2), F323-F331.

Lee, S. J., Kang, H. K., Eum, W. S., Park, J., Choi, S. Y., & Kwon, H. Y. (2017). Tat‐biliverdin reductase A protects INS‐1 cells from human islet amyloid polypeptide‐induced cytotoxicity by alleviating oxidative stress and ER stress. Cell biology international, 41(5), 514-524.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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