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Mouse Anti-BTLA Recombinant Antibody (CBYY-0899) (CBMAB-0902-YY)

This product is mouse antibody that recognizes BTLA. The antibody CBYY-0899 can be used for immunoassay techniques such as: WB
See all BTLA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0899
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human BTLA(NP_861445) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
B And T Lymphocyte Associated
Introduction
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. PolymorphisMouse in this gene have been associated with an increased risk of rheumatoid arthritis.
Entrez Gene ID
UniProt ID
Alternative Names
B And T Lymphocyte Associated; B- And T-Lymphocyte-Associated Protein; B- And T-Lymphocyte Attenuator; CD272 Antigen; BTLA1; CD272;
Function
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050).
May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response-regulating cell surface receptor signaling pathway Source: GO_Central
T cell costimulation Source: Reactome
Cellular Location
Cell membrane
Topology
Extracellular: 31-157 aa
Helical: 158-178 aa
Cytoplasmic: 179-289 aa
PTM
Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.

Ning, Z., Liu, K., & Xiong, H. (2021). Roles of BTLA in immunity and immune disorders. Frontiers in Immunology, 12.

Deng, Z., Zheng, Y., Cai, P., & Zheng, Z. (2021). The Role of B and T Lymphocyte Attenuator in Respiratory System Diseases. Frontiers in Immunology, 12, 2141.

Wiedemann, A., Lettau, M., Weißenberg, S. Y., Stefanski, A. L., Schrezenmeier, E. V., Rincon-Arevalo, H., ... & Dörner, T. (2021). BTLA Expression and Function Are Impaired on SLE B Cells. Frontiers in immunology, 12, 1402.

Axelsson, S., Magnuson, A., Lange, A., Alshamari, A., Hörnquist, E. H., & Hultgren, O. (2020). A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex. BMC immunology, 21(1), 1-9.

Zhang, H., Wang, Z., Zhang, J., Zhang, X., Gui, Z., Sun, L., ... & Gu, M. (2020). The synergism of B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) attenuated acute T-cell mediated rejection and prolonged renal graft survival. Translational Andrology and Urology, 9(5), 1990.

Karabon, L., Partyka, A., Ciszak, L., Pawlak-Adamska, E., Tomkiewicz, A., Bojarska-Junak, A., ... & Kosmaczewska, A. (2020). Abnormal expression of BTLA and CTLA-4 immune checkpoint molecules in chronic lymphocytic leukemia patients. Journal of immunology research, 2020.

Yu, X., Zheng, Y., Mao, R., Su, Z., & Zhang, J. (2019). BTLA/HVEM signaling: milestones in research and role in chronic hepatitis B virus infection. Frontiers in immunology, 10, 617.

Monaghan, S. F., Banerjee, D., Chung, C. S., Lomas-Neira, J., Cygan, K. J., Rhine, C. L., ... & Ayala, A. (2018). Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Molecular Medicine, 24(1), 1-7.

Sawaf, M., Fauny, J. D., Felten, R., Sagez, F., Gottenberg, J. E., Dumortier, H., & Monneaux, F. (2018). Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells. Jci Insight, 3(13).

Lan, X., Li, S., Gao, H., Nanding, A., Quan, L., Yang, C., ... & Xue, Y. (2017). Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis. OncoTargets and therapy, 10, 919.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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