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BTLA

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

Full Name

B And T Lymphocyte Associated

Function

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050).
May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).

Biological Process

Adaptive immune response Source: UniProtKB-KW
Immune response-regulating cell surface receptor signaling pathway Source: GO_Central
T cell costimulation Source: Reactome

Cellular Location

Cell membrane

Topology

Extracellular: 31-157 aa
Helical: 158-178 aa
Cytoplasmic: 179-289 aa

PTM

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.

Anti-BTLA antibodies

Mouse Anti-BTLA Recombinant Antibody (CBYY-C0783) (CBMAB-C2219-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0783

Application*: WB, IF

Mouse Anti-BTLA Recombinant Antibody (CBYY-C0707) (CBMAB-C2092-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYY-C0707

Application*: F

Mouse Anti-BTLA Recombinant Antibody (CBYY-C0549) (CBMAB-C1662-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYY-C0549

Application*: F, FN, N

Hamster Anti-BTLA Recombinant Antibody (CBYY-C0530) (CBMAB-C1573-YY)

SDS

Target: BTLA

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYY-C0530

Application*: F, IP, B

Mouse Anti-BTLA Recombinant Antibody (4B8) (CBMAB-A0905-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4B8

Application*: WB, E

Mouse Anti-BTLA Recombinant Antibody (1B7) (CBMAB-A0903-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1B7

Application*: WB, E

Mouse Anti-BTLA Recombinant Antibody (MIH26) (CBMAB-C9510-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: MIH26

Application*: F

Mouse Anti-BTLA Recombinant Antibody (6G3) (CBMAB-C8310-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: 6G3

Application*: F

Hamster Anti-BTLA Recombinant Antibody (6A6) (CBMAB-C8058-LY)

SDS

Target: BTLA

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: 6A6

Application*: F

Mouse Anti-BTLA Recombinant Antibody (4D6) (CBMAB-C6797-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4D6

Application*: WB, IC/IF

Mouse Anti-BTLA Recombinant Antibody (CBYY-0904) (CBMAB-0907-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Monkey, Dog

Clone: CBYY-0904

Application*: WB, IH

Mouse Anti-BTLA Recombinant Antibody (CBYY-0903) (CBMAB-0906-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0903

Application*: WB, IH, IF

Mouse Anti-BTLA Recombinant Antibody (CBYY-0902) (CBMAB-0905-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0902

Application*: WB, IH

Mouse Anti-BTLA Recombinant Antibody (CBYY-0901) (CBMAB-0904-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0901

Application*: WB

Mouse Anti-BTLA (N-Terminus) Recombinant Antibody (CBYY-0900) (CBMAB-0903-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0900

Application*: WB, IF

Mouse Anti-BTLA Recombinant Antibody (CBYY-0899) (CBMAB-0902-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-0899

Application*: WB

Mouse Anti-BTLA Recombinant Antibody (CBYY-0898) (CBMAB-0901-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0898

Application*: WB, IF, F

Mouse Anti-BTLA Recombinant Antibody (CBYY-0897) (CBMAB-0900-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-0897

Application*: WB

Mouse Anti-BTLA Recombinant Antibody (CBYY-0896) (CBMAB-0899-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-0896

Application*: WB, IH, F

Mouse Anti-BTLA Recombinant Antibody (CBYY-0894) (CBMAB-0897-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-0894

Application*: WB

Rat Anti-BTLA Recombinant Antibody (CBYY-0893) (CBMAB-0896-YY)

SDS

Target: BTLA

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-0893

Application*: E, WB

Rat Anti-BTLA Recombinant Antibody (CBYY-0892) (CBMAB-0895-YY)

SDS

Target: BTLA

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-0892

Application*: E, F, FN

Mouse Anti-BTLA Recombinant Antibody (CBYY-0890) (CBMAB-0893-YY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-0890

Application*: WB, IP, IF, E

Rabbit Anti-BTLA Recombinant Antibody (EG428) (CBMAB-EN487-LY)

SDS

Target: BTLA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG428

Application*: WB: 1:500~1:3000 ELISA: 1:40000

Rat Anti-BTLA Recombinant Antibody (A018) (CBMAB-AP12024LY)

SDS

Target: BTLA

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: A018

Application*: FC

Mouse Anti-BTLA Recombinant Antibody (PJ196) (CBMAB-0961-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: PJ196

Application*: B, A, F

Armenian Hamster Anti-BTLA Recombinant Antibody (6A6) (CBMAB-0960-LY)

SDS

Target: BTLA

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: 6A6

Application*: B

Mouse Anti-BTLA Recombinant Antibody (8F4) (CBMAB-0959-LY)

SDS

Target: BTLA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 8F4

Application*: F

Rat Anti-BTLA Recombinant Antibody (PK18.6) (CBMAB-0958-LY)

SDS

Target: BTLA

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: PK18.6

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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