BTLA

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Full Name
B And T Lymphocyte Associated
Function
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050).
May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response-regulating cell surface receptor signaling pathway Source: GO_Central
T cell costimulation Source: Reactome
Cellular Location
Cell membrane
Topology
Extracellular: 31-157 aa
Helical: 158-178 aa
Cytoplasmic: 179-289 aa
PTM
Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.
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Anti-BTLA antibodies

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Rat Anti-BTLA Recombinant Antibody (PK18.6) (CBMAB-C8310-LY)

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Target: BTLA
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: PK18.6
Application*: In vivo, FC
In Vivo Assay
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (1B7) (CBMAB-A0903-LY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B7
Application*: WB, E
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (6G3) (CBMAB-C9510-LY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 6G3
Application*: FC
Datasheet SDS

Human Anti-BTLA Recombinant Antibody (
10A10) (V2LY-0725-LY1346)

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Target: BTLA
Host: Human
Antibody Isotype: IgG4
Specificity: Human
Clone: 10A10
Application*: E, F
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBT3701) (V2LY-0625-LY999)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3701
Application*: F
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBT3033) (V2LY-0625-LY837)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3033
Application*: F
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBT4810) (V2LY-0625-LY836)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4810
Application*: IC
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBT2608) (V2LY-0625-LY1000)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2608
Application*: F
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBYY-C0549) (CBMAB-C1662-YY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0549
Application*: In vivo, FC
In Vivo Assay
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBYY-0904) (CBMAB-0907-YY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-0904
Application*: In vivo, FC
In Vivo Assay
Datasheet SDS

Hamster Anti-BTLA Recombinant Antibody (CBYY-0899) (CBMAB-0902-YY)

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Target: BTLA
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-0899
Application*: In vivo, FC
In Vivo Assay
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBYY-0898) (CBMAB-0901-YY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-0898
Application*: In vivo, FC
In Vivo Assay
Datasheet SDS

Hamster Anti-BTLA Recombinant Antibody (CBYY-0897) (CBMAB-0900-YY)

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Target: BTLA
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-0897
Application*: In vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-BTLA Recombinant Antibody (CBYY-0890) (CBMAB-0893-YY)

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Target: BTLA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-0890
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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