Full length recombinant corresponding to aa1-1085 from human BUB1 (AAH28201.1) with GST tag. MW of the GST tag alone is 26kD
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forMouse of cancer. Alternate splicing results in multiple transcript variants.
BUB1 Mitotic Checkpoint Serine/Threonine Kinase; BUB1L; BUB1A; HBUB1; Budding Uninhibited By Benzimidazoles 1 (Yeast Homolog); Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast); Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1;