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Mouse Anti-CABIN1 Recombinant Antibody (2G2) (CBMAB-C5160-LY)

This product is antibody recognizes CABIN1. The antibody 2G2 immunoassay techniques such as: ELISA, WB.
See all CABIN1 antibodies
Published Data
Fig.1 Representative results of western blot analyses for specific interaction between endogenous PHB and other indicated proteins in SHhES8 hESCs.
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Fig.2 Representative results of WB analyses for distribution of PHB, H3.3, CABIN1, UBN1, and HIRA proteins in the cytoplasm, soluble nuclei, and chromatin extracts of SHhES8 hESCs.
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Fig.3 Representative results of WB analyses showing specific interaction of endogenous PHB with HIRA, UBN1, and CABIN1 proteins in the soluble nuclear fraction of SHhES8 hESCs.
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Fig.4 Knockdown of PHB in SHhES8 hESCs reduces the protein levels of CABIN1, UBN1, and HIRA. Samples were collected 4 days after siRNA transfection.
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Fig.5 Representative results of WB analyses for protein levels of PHB, HIRA, UBN1, CABIN1, IDH1, IDH2, and H3 lysine methylation levels in the samples.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-111 from CABIN1 (NP_036427) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
calcineurin binding protein 1
Entrez Gene ID
23523
UniProt ID
Q9Y6J0
Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB
Cellular Location
Nucleus
PTM
Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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