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Mouse Anti-CABIN1 Recombinant Antibody (B1) (CBMAB-C9601-LY)


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Published Data
CBMAB-C9601-LY-1
Mouse Anti-CABIN1 Recombinant Antibody (B1) (CBMAB-C9601-LY) in WB
Western blot analysis of the indicated proteins in HIRA members and Asf1a-depleted ESCs. Actin was included as a loading control. c-g qPCR analysis of the expression level of pluripotency genes (Oct4, Sox2, and Nanog) in HIRA members Hira. ...View More
Zhang, M., Zhao, X., Feng, X., Hu, X., Zhao, X., Lu, W., & Lu, X. (2022). Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells. Stem Cell Research & Therapy, 13(1), 137.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B1
Antibody Isotype
IgM, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 2169-2188 near the C-terminus of Cabin-1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
calcineurin binding protein 1
Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB
Cellular Location
Nucleus
PTM
Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.
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For research use only. Not intended for any clinical use.

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