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CABIN1

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Full Name

calcineurin binding protein 1

Function

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.

Biological Process

Cell surface receptor signaling pathway Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB

Cellular Location

Nucleus

PTM

Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.

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Anti-CABIN1 antibodies

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Rabbit Anti-CABIN1 Recombinant Antibody (D2B9F) (CBMAB-CP0060-LY)

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Target: CABIN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D2B9F

Application*: WB, IP

Mouse Anti-CABIN1 Recombinant Antibody (CBLC047-LY) (CBMAB-C9600-LY)

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Target: CABIN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLC047-LY

Application*: WB, IP, IF, E

Mouse Anti-CABIN1 Recombinant Antibody (B1) (CBMAB-C9601-LY)

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Target: CABIN1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: B1

Application*: WB, IP, IF, E

Mouse Anti-CABIN1 Recombinant Antibody (2G2) (CBMAB-C5160-LY)

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Target: CABIN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G2

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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