Mouse Anti-CABIN1 Recombinant Antibody (CBLC047-LY) (CBMAB-C9600-LY)

Name: Mouse Anti-CABIN1 Recombinant Antibody (CBLC047-LY)
SKU: CBMAB-C9600-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLC047-LY

Application

WB, IP, IF, E

Immunogen

Amino acids 1-300 mapping at the N-terminus of Cabin-1 of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

calcineurin binding protein 1

Entrez Gene ID

Human	23523
Rat	94165
Mouse	104248

UniProt ID

Human	Q9Y6J0
Rat	O88480
Mouse	Q3TGB0

Function

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.

Biological Process

Cell surface receptor signaling pathway Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB

Cellular Location

Nucleus

PTM

Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.

Mallick, A., Taylor, S. K., Mehta, S., & Gupta, B. P. (2021). picd-1, a gene that encodes CABIN1 domain-containing protein, interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans. bioRxiv.

Wen, Y., Chen, J., Liu, L., Guo, G., Zeng, Y., Zhang, Y., ... & Liang, J. (2020). Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway. Journal of Receptors and Signal Transduction, 40(2), 141-147.

Exline, J. (2019). The Effects of Cabin1 in Auditory and Vestibular Function of Zebrafish.

Waters, H. (2018). Cabin1 is vital for growth and survival of larvae zebrafish.

Zhang, L., Zhou, L., Shi, M., Kuang, Y., & Fang, L. (2018). Downregulation of miRNA‑15a and miRNA‑16 promote tumor proliferation in multiple myeloma by increasing CABIN1 expression. Oncology letters, 15(1), 1287-1296.

Wen, Y., Li, H., Zhou, P., Liu, L., Wang, Z., & Liang, J. (2017). Upregulation of Cabin1 during injury to renal tubular epithelial cells in rats. Iranian journal of kidney diseases, 11(6), 430.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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