Rat Anti-CADM4 Recombinant Antibody (CBYY-I1277) (CBMAB-I2446-YY)

Name: Rat Anti-CADM4 Recombinant Antibody (CBYY-I1277)
SKU: CBMAB-I2446-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-I1277

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human IGSF4C/SynCAM4 Gln25-Tyr323.

Host Species

Rat

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cell Adhesion Molecule 4

Introduction

CADM4 (Cell Adhesion Molecule 4) is a Protein Coding gene. Diseases associated with CADM4 include Renal Clear Cell Carcinoma and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome.

Entrez Gene ID

3552

UniProt ID

P01583

Alternative Names

Cell Adhesion Molecule 4; Immunoglobulin Superfamily Member 4C; Nectin-Like Protein 4; TSLC1-Like Protein 2; Nectin-Like 4; Necl-4; IGSF4C;

Function

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

Biological Process

Cell adhesion Source: UniProtKB-KW
Negative regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
Regulation of cell motility Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of protein phosphorylation Source: UniProtKB
Regulation of Rac protein signal transduction Source: UniProtKB
Regulation of wound healing Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 21-324 aa
Helical: 325-345 aa
Cytoplasmic: 346-388 aa

PTM

N-glycosylated.

Luo, F., Zhao, Y., & Liu, J. (2020). Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer. The international journal of biochemistry & cell biology, 123, 105750.

Elazar, N., Vainshtein, A., Golan, N., Vijayaragavan, B., Schaeren-Wiemers, N., Eshed-Eisenbach, Y., & Peles, E. (2019). Axoglial adhesion by Cadm4 regulates CNS myelination. Neuron, 101(2), 224-231.

Meng, X., Maurel, P., Lam, I., Heffernan, C., Stiffler, M. A., McBeath, G., & Salzer, J. L. (2019). Necl‐4/Cadm4 recruits Par‐3 to the Schwann cell adaxonal membrane. Glia, 67(5), 884-895.

Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., ... & Takenoshita, S. (2018). Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncology letters, 15(2), 2401-2406.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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