Human Recombinant CADM4 protein, hFc Tag (V2LY-0526-LY2505)

Name: Human Recombinant CADM4 protein, hFc Tag
SKU: V2LY-0526-LY2505
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant CADM4 protein, hFc Tag consist of Amino Acid: 1-323 and predicts a molecular mass of 60.1 kDa.

Molecule Mass

60.1 kDa

Sequence

Amino Acid: 1-323

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cell Adhesion Molecule 4

Function

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

Biological Process

Cell adhesion Source: UniProtKB-KW
Negative regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
Regulation of cell motility Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of protein phosphorylation Source: UniProtKB
Regulation of Rac protein signal transduction Source: UniProtKB
Regulation of wound healing Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 21-324 aa
Helical: 325-345 aa
Cytoplasmic: 346-388 aa

PTM

N-glycosylated.

Luo, F., Zhao, Y., & Liu, J. (2020). Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer. The international journal of biochemistry & cell biology, 123, 105750.

Elazar, N., Vainshtein, A., Golan, N., Vijayaragavan, B., Schaeren-Wiemers, N., Eshed-Eisenbach, Y., & Peles, E. (2019). Axoglial adhesion by Cadm4 regulates CNS myelination. Neuron, 101(2), 224-231.

Meng, X., Maurel, P., Lam, I., Heffernan, C., Stiffler, M. A., McBeath, G., & Salzer, J. L. (2019). Necl‐4/Cadm4 recruits Par‐3 to the Schwann cell adaxonal membrane. Glia, 67(5), 884-895.

Saito, M., Goto, A., Abe, N., Saito, K., Maeda, D., Ohtake, T., ... & Takenoshita, S. (2018). Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncology letters, 15(2), 2401-2406.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CADM4 protein, ECD, His Tag (CAT#: V2LY-0526-LY2504)

Mouse Recombinant CADM4 protein, His Tag (CAT#: V2LY-0526-LY7899)

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Rat Anti-CADM4 Recombinant Antibody (CBYY-C0868) (CAT#: CBMAB-C2304-YY)

Rabbit Anti-CADM4 Recombinant Antibody (EG460) (CAT#: CBMAB-EN520-LY)

Mouse Recombinant CADM4 protein, His Tag (CAT#: V2LY-0526-LY7899)

Rat Anti-CADM4 Recombinant Antibody (CBYY-I1277) (CAT#: CBMAB-I2446-YY)

Human Recombinant CADM4 protein, ECD, His Tag (CAT#: V2LY-0526-LY2504)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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