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Rabbit Anti-CALD1 (C-terminus) Recombinant Antibody (CBFYC-0748) (CBMAB-C0803-FY)

This product is rabbit antibody that recognizes CALD1. The antibody CBFYC-0748 can be used for immunoassay techniques such as: IF, IP, WB.
See all CALD1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYC-0748
Antibody Isotype
IgG
Application
IF, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the C-terminal domain of human caldesmon-1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM Sodium HEPES, pH 7.5, 150 mM NaCl, 0.01% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Caldesmon 1
Introduction
CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include Mixed Endometrial Stromal And Smooth Muscle Tumor and Kidney Leiomyosarcoma. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and myosin binding.
Entrez Gene ID
Human800
Mouse109624
Rat25687
UniProt ID
HumanQ05682
MouseE9QA16
RatQ62736
Alternative Names
Caldesmon 1; CDM; Testis Secretory Sperm-Binding Protein Li 227n; Caldesmon; H-CAD; L-CAD
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Biological Process
Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome
Cellular Location
Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
PTM
In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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