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CALD1

CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include Mixed Endometrial Stromal And Smooth Muscle Tumor and Kidney Leiomyosarcoma. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and myosin binding.

Full Name

Caldesmon 1

Function

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Biological Process

Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome

Cellular Location

Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).

PTM

In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).

Anti-CALD1 antibodies

Mouse Anti-CALD1 Recombinant Antibody (CBXC-0046) (CBMAB-C5302-CQ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0046

Application*: IF, IH, WB

Mouse Anti-CALD1 Recombinant Antibody (SPM168) (CBMAB-C1068-CQ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: SPM168

Application*: F, P, IF

Mouse Anti-CALD1 Recombinant Antibody (h-CALD) (CBMAB-C0687-CQ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: h-CALD

Application*: WB, F, P, IF, MC

Mouse Anti-CALD1 Recombinant Antibody (CALD1/820) (CBMAB-C0516-CQ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CALD1/820

Application*: F, P, IF

Rabbit Anti-CALD1 Recombinant Antibody (CALD1/1424R) (CBMAB-C0515-CQ)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG, κ

Specificity: Human, Rat

Clone: CALD1/1424R

Application*: F, IF, P

Rabbit Anti-CALD1 Recombinant Antibody (CALD1/1424) (CBMAB-C0514-CQ)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CALD1/1424

Application*: F, P, IF

Mouse Anti-CALD1 Recombinant Antibody (CBXC-2388) (CBMAB-C0018-CQ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Avian, Chicken

Clone: CBXC-2388

Application*: WB, E

Rabbit Anti-CALD1 (C-terminus) Recombinant Antibody (CBFYC-0748) (CBMAB-C0803-FY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYC-0748

Application*: IF, IP, WB

Mouse Anti-CALD1 Recombinant Antibody (CBFYC-0747) (CBMAB-C0802-FY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYC-0747

Application*: IH, IP, WB

Mouse Anti-CALD1 Recombinant Antibody (CBFYC-0251) (CBMAB-C0281-FY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Bird, Duck, Human

Clone: CBFYC-0251

Application*: E, WB

Mouse Anti-CALD1 Recombinant Antibody (CBYJL-127) (CBMAB-L0190-YJ)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYJL-127

Application*: WB, IF

Mouse Anti-CALD1 Recombinant Antibody (2B5) (CBMAB-C4696-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Duck, Chicken, Human

Clone: 2B5

Application*: E, WB

Mouse Anti-CALD1 Recombinant Antibody (10B424) (CBMAB-C2251-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Duck, Chicken, Human

Clone: 10B424

Application*: E, WB

Mouse Anti-CALD1 Recombinant Antibody (12B5) (CBMAB-C0273-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Bird, Chicken

Clone: 12B5

Application*: WB, E

Rabbit Anti-CALD1 Recombinant Antibody (CAP291) (CBMAB-AP751LY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP291

Application*: FC, ICC, IF, IHC, WB

Mouse Anti-CALD1 Recombinant Antibody (1C1) (CBMAB-AP749LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1C1

Application*: IHC

Mouse Anti-CALD1 Recombinant Antibody (hHCD) (CBMAB-AP748LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rabbit

Clone: hHCD

Application*: IHC, WB

Rabbit Anti-CALD1 Recombinant Antibody (CAP290) (CBMAB-AP747LY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP290

Application*: FC, ICC, IF, IHC, IP, WB

Mouse Anti-CALD1 Recombinant Antibody (CBMAB-AO146LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Application*: ELISA, WB, IHC

Recombinant Rabbit Anti-CALD1 Antibody (CBAb037) (CBMAB-Ab037-LY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb037

Application*: WB, IH, IF, IP

Mouse Anti-CALD1 Recombinant Antibody (IHC522) (CBMAB-MA029-YC)

SDS

Target: CALD1

Host: Mouse

Specificity: Human

Clone: IHC522

Application*: IH

Mouse Anti-CALD1 Recombinant Antibody (TD107) (CBMAB-C9651-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: TD107

Application*: IC, IH, WB

Rabbit Anti-CALD1 Recombinant Antibody (RMCDN1-1) (CBMAB-C9648-LY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: RMCDN1-1

Application*: IF, P

Rabbit Anti-CALD1 Recombinant Antibody (SP226) (CBMAB-P0131-YC)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Chicken

Clone: SP226

Application*: WB, F, P

Mouse Anti-CALD1 Recombinant Antibody (CBYY-C0569) (CBMAB-C1764-YY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0569

Application*: WB, IC

Mouse Anti-CALD1 Recombinant Antibody (767001) (CBMAB-C8523-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 767001

Application*: WB, IC

Mouse Anti-CALD1 Recombinant Antibody (2Q1096) (CBMAB-C5326-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2Q1096

Application*: WB, IP, IH, IF

rabbit Anti-CALD1 Recombinant Antibody (13G23D5C8D) (CBMAB-C2884-LY)

SDS

Target: CALD1

Host: rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: 13G23D5C8D

Application*: IF, IP, WB

Mouse Anti-CALD1 Recombinant Antibody (10K120) (CBMAB-C2363-LY)

SDS

Target: CALD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 10K120

Application*: IH, IP, WB

Rabbit Anti-CALD1 Monoclonal Antibody (CBFYR-0008) (CBMAB-R0013-FY)

SDS

Target: CALD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYR-0008

Application*: ELISA

CALD1 Matched Antibody Pair (169) (APMAB-169LY)

SDS

Target: CALD1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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