CALD1
CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include Mixed Endometrial Stromal And Smooth Muscle Tumor and Kidney Leiomyosarcoma. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and myosin binding.
Full Name
Caldesmon 1
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Biological Process
Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome
Cellular Location
Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
PTM
In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
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Anti-CALD1 antibodies
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CompareTarget: CALD1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYJL-127
Application*: WB, IF, IP
Target: CALD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb037
Application*: WB, IH, IF, IP, F
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: h-CALD
Application*: IF, IP, WB, P
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CALD1/820
Application*: WB, IH
Target: CALD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-0748
Application*: WB, IH
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0747
Application*: IF, IP, WB, E, P
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0251
Application*: IF, IP, WB, E
Target: CALD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 767001
Application*: WB, IC, IH
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2104
Application*: WB, IH, F
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4092
Application*: IH, F
Target: CALD1
Specificity: Human
Target: CALD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit
Clone: CBYY-C0569
Application*: WB, IH
Target: CALD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0008
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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