Mouse Anti-CALD1 Recombinant Antibody (CBYY-C0569) (CBMAB-C1764-YY)

Name: Mouse Anti-CALD1 Recombinant Antibody (CBYY-C0569)
SKU: CBMAB-C1764-YY
Rating: 5 (1 reviews)

See all CALD1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C0569

Application

WB, IHC

Immunogen

Human uterus smooth muscle extract.

Host Species

Mouse

Specificity

Human, Mouse, Rabbit

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	0.25-0.5 µg/ml
IHC	0.5-1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

2mg BSA

Preservative

0.01% sodum azide, 1.2% sodium acetate

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Caldesmon 1

Entrez Gene ID

800

UniProt ID

Q05682

Alternative Names

Creatine Kinase B; Creatine Kinase Brain-Type; Creatine Kinase B Chain; EC 2.7.3.2; CKBB; B-CK; Epididymis Secretory Protein Li 29; Epididymis Luminal Protein 211;

Function

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Biological Process

Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome

Cellular Location

Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).

PTM

In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).

Papke, D. J., Oliveira, A. M., Chou, M. M., & Fletcher, C. D. (2021). Morphologically malignant nodular fasciitis with CALD1-USP6 fusion. Virchows Archiv, 1-6.

Mamoor, S. (2021). CALD1 is differentially expressed in lymph node metastasis in human breast cancer.

Zheng, H., Bai, Y., Wang, J., Chen, S., Zhang, J., Zhu, J., ... & Wang, X. (2021). Weighted Gene Co-expression Network Analysis Identifies CALD1 as a Biomarker Related to M2 Macrophages Infiltration in Stage III and IV Mismatch Repair-Proficient Colorectal Carcinoma. Frontiers in molecular biosciences, 8.

Cheng, Q., Tang, A., Wang, Z., Fang, N., Zhang, Z., Zhang, L., ... & Zeng, Y. (2021). CALD1 Modulates Gliomas Progression via Facilitating Tumor Angiogenesis. Cancers, 13(11), 2705.

Śnit, M., Nabrdalik, K., Długaszek, M., Gumprecht, J., Trautsolt, W., Górczyńska-Kosiorz, S., & Grzeszczak, W. (2017). Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes—preliminary results of a family-based study. Endokrynologia Polska, 68(1), 13-17.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CALD1 Recombinant Antibody (CBYY-C0569)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

Related Products

Mouse Anti-CALD1 Recombinant Antibody (CBFYC-0251) (CAT#: CBMAB-C0281-FY)

Mouse Anti-CALD1 Recombinant Antibody (767001) (CAT#: CBMAB-C8523-LY)

Mouse Anti-CALD1 Recombinant Antibody (CBT4092) (CAT#: V2LY-0625-LY1277)

Mouse Anti-CALD1 Recombinant Antibody (CALD1/820) (CAT#: CBMAB-C0516-CQ)

Mouse Anti-CALD1 Recombinant Antibody (CBFYC-0747) (CAT#: CBMAB-C0802-FY)

CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

Rabbit Anti-CALD1 Monoclonal Antibody (CBFYR-0008) (CAT#: CBMAB-R0013-FY)

Mouse Anti-CALD1 Recombinant Antibody (CBYJL-127) (CAT#: CBMAB-L0190-YJ)

Rabbit Anti-CALD1 Recombinant Antibody (CBAb037) (CAT#: CBMAB-Ab037-LY)

Mouse Anti-CALD1 Recombinant Antibody (h-CALD) (CAT#: CBMAB-C0687-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry