Mouse Anti-CALD1 Recombinant Antibody (h-CALD) (CBMAB-C0687-CQ)

Name: Mouse Anti-CALD1 Recombinant Antibody (h-CALD)
SKU: CBMAB-C0687-CQ
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CALD1 Recombinant Antibody (h-CALD) (CBMAB-C0687-CQ) in IHC

Histopathological features of the three cases of our cohort. Each line represents one patient (cases #1 to #3 from top to bottom). Cavernous-type pattern composed of dilated vascular channels with variable thickening of the walls (A, D, G, HPS, magnification × 100) with some perivascular concentric arrangement of myoid cells (insert magnification × 400). The vascular cavities were lined by endothelial cells stained by CD34 (B, E, H, magnification × 100). In the walls of vascular structure, the tumor cells were diffusely immunoreactive for h-caldesmon (C, F and I, magnification × 100). Black scale bars represent 250 μm (A-I) and 50 µm (insert). ...View More

Tauziède-Espariat, A., Pierre, T., Wassef, M., Castel, D., Riant, F., Grill, J., ... & RENOCLIP-LOC. (2022). The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile. Acta Neuropathologica Communications, 10(1), 81.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

h-CALD

Application

IF, IP, WB, IHC-P

Immunogen

Crude human uterus extract.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Caldesmon 1

Introduction

CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include Mixed Endometrial Stromal And Smooth Muscle Tumor and Kidney Leiomyosarcoma. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and myosin binding.

Entrez Gene ID

800

UniProt ID

Q05682

Alternative Names

Caldesmon 1; CDM; Testis Secretory Sperm-Binding Protein Li 227n; Caldesmon; H-CAD; L-CAD;

Function

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Biological Process

Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome

Cellular Location

Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).

PTM

In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).

Papke, D. J., Oliveira, A. M., Chou, M. M., & Fletcher, C. D. (2021). Morphologically malignant nodular fasciitis with CALD1-USP6 fusion. Virchows Archiv, 1-6.

Mamoor, S. (2021). CALD1 is differentially expressed in lymph node metastasis in human breast cancer.

Zheng, H., Bai, Y., Wang, J., Chen, S., Zhang, J., Zhu, J., ... & Wang, X. (2021). Weighted Gene Co-expression Network Analysis Identifies CALD1 as a Biomarker Related to M2 Macrophages Infiltration in Stage III and IV Mismatch Repair-Proficient Colorectal Carcinoma. Frontiers in molecular biosciences, 8.

Cheng, Q., Tang, A., Wang, Z., Fang, N., Zhang, Z., Zhang, L., ... & Zeng, Y. (2021). CALD1 Modulates Gliomas Progression via Facilitating Tumor Angiogenesis. Cancers, 13(11), 2705.

Śnit, M., Nabrdalik, K., Długaszek, M., Gumprecht, J., Trautsolt, W., Górczyńska-Kosiorz, S., & Grzeszczak, W. (2017). Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes—preliminary results of a family-based study. Endokrynologia Polska, 68(1), 13-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

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Isotype control

For research use only. Not intended for any clinical use.

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