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Rabbit Anti-CAPZB Recombinant Antibody (CBXC-0066) (CBMAB-C5067-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXC-0066
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Ile21 of human CAPZB protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
capping protein (actin filament) muscle Z-line, beta
Introduction
This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility.
Entrez Gene ID
832
UniProt ID
P47756
Alternative Names
Capping Actin Protein Of Muscle Z-Line Beta Subunit; Capping Protein (Actin Filament) Muscle Z-Line, Beta; CapZ Beta; F-Actin-Capping Protein Subunit Beta; CAPPB; CAPZ; CAPB;
Function
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Biological Process
Actin cytoskeleton organization Source: InterPro
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Blood coagulation Source: Reactome
Cell morphogenesis Source: GO_Central
Cytoskeleton organization Source: UniProtKB
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Negative regulation of filopodium assembly Source: GO_Central
Regulation of cell morphogenesis Source: UniProtKB
Regulation of lamellipodium assembly Source: GO_Central
Cellular Location
Cytoskeleton; Sarcomere
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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