Sign in or Register   Sign in or Register
  |  

Mouse Anti-CARS Recombinant Antibody (CBXC-1880) (CBMAB-C5087-CQ)

This product is a mouse antibody that recognizes CARS. The antibody CBXC-1880 can be used for immunoassay techniques such as: WB, IHC.
See all CARS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1880
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Recombinant Protein corresponding to amino acids:SQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVE
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cysteinyl-TRNA Synthetase
Introduction
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
833
UniProt ID
P49589
Alternative Names
Cysteinyl-TRNA Synthetase; Cysteine TRNA Ligase 1, Cytoplasmic; EC 6.1.1.16; CYSRS; Cysteine--TRNA Ligase, Cytoplasmic; Cysteine Translase; MGC:11246; EC 6.1.1; CARS1;
Function
Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
Biological Process
Cysteinyl-tRNA aminoacylation Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome
Cellular Location
Cytoplasm
Involvement in disease
Microcephaly, developmental delay, and brittle hair syndrome (MDBH): An autosomal recessive disorder characterized by developmental delay, motor and cognitive disabilities, brittle hair and nails, failure to thrive, and short stature.

Meng, Q., Li, C. X., & Long, D. (2021). CARS as a Prognosis Factor in Clear Cell Renal Cell Carcinoma and Its Association with Tumor Immunity. International Journal of General Medicine, 14, 3197.

Yuan, M., Yan, R., Zhang, Y., Qiu, Y., Jiang, Z., Liu, H., ... & Gao, P. (2021). CARS senses cysteine deprivation to activate AMPK for cell survival. The EMBO Journal, 40(21), e108028.

Kuo, M. E., Theil, A. F., Kievit, A., Malicdan, M. C., Introne, W. J., Christian, T., ... & Mancini, G. M. (2019). Cysteinyl-tRNA synthetase mutations cause a multi-system, recessive disease that includes microcephaly, developmental delay, and brittle hair and nails. The American Journal of Human Genetics, 104(3), 520-529.

Nishimura, A., Nasuno, R., Yoshikawa, Y., Jung, M., Ida, T., Matsunaga, T., ... & Akaike, T. (2019). Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells. Journal of Biological Chemistry, 294(37), 13781-13788.

Akaike, T., Motohashi, H., Fukuto, J., & Nagy, P. (2018). Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mitochondrial respiration. Free Radical Biology and Medicine, 120, S21.

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., ... & Motohashi, H. (2017). Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nature communications, 8(1), 1-15.

Ida, T., Nishimura, A., Morita, M., Motohashi, H., & Akaike, T. (2017). Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases. Free Radical Biology and Medicine, 112, 189-190.

Akaike, T., Nishimura, A., Ida, T., Matsunaga, T., Morita, M., & Motohashi, H. (2017). Moonlighting Functions of Cysteinyl-tRNA Synthetases: Cycteine Hydropersulfide Production and Regulation of Mitochondrial Biogenesis and Bioenergetics. Free Radical Biology and Medicine, 112, 182-183.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CARS Recombinant Antibody (CBXC-1880)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare