CARS

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Full Name
Cysteinyl-TRNA Synthetase
Function
Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
Biological Process
Cysteinyl-tRNA aminoacylation Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome
Cellular Location
Cytoplasm
Involvement in disease
Microcephaly, developmental delay, and brittle hair syndrome (MDBH): An autosomal recessive disorder characterized by developmental delay, motor and cognitive disabilities, brittle hair and nails, failure to thrive, and short stature.
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Anti-CARS antibodies

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Mouse Anti-CARS Recombinant Antibody (CBXC-1880) (CBMAB-C5087-CQ)

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Target: CARS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1880
Application*: WB, IH
Datasheet SDS

Rabbit Anti-CARS Recombinant Antibody (CBXC-1879) (CBMAB-C5086-CQ)

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Target: CARS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXC-1879
Application*: WB, E, P
Datasheet SDS

Rabbit Anti-CARS Recombinant Antibody (
8B11) (V2LY-0725-LY974)

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Target: CARS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8B11
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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