Mouse Anti-CCL28 Recombinant Antibody (CBXC-1266) (CBMAB-C5789-CQ)

Name: Mouse Anti-CCL28 Recombinant Antibody (CBXC-1266)
SKU: CBMAB-C5789-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1266

Application

Neutralization, WB

Immunogen

Human recombinant CCL-28.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

0.5 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 28

Introduction

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene.

Entrez Gene ID

56477

UniProt ID

Q9NRJ3

Alternative Names

C-C Motif Chemokine Ligand 28; Mucosae-Associated Epithelial Chemokine; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28; Small Inducible Cytokine A28; CC Chemokine CCL28; SCYA28; MEC;

Function

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Chemotaxis Source: UniProtKB
Cytolysis in other organism Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: InterPro
Killing of cells of other organism Source: UniProtKB
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Response to nutrient Source: Ensembl

Cellular Location

Secreted

Iwamoto, R., Takahashi, T., Yoshimi, K., Imai, Y., Koide, T., Hara, M., ... & Yukita, A. (2021). Chemokine ligand 28 (CCL28) negatively regulates trabecular bone mass by suppressing osteoblast and osteoclast activities. Journal of Bone and Mineral Metabolism, 1-14.

Liu, B., & Wei, C. (2021). Hypoxia Induces Overexpression of CCL28 to Recruit Treg Cells to Enhance Angiogenesis in Lung Adenocarcinoma. Journal of Environmental Pathology, Toxicology and Oncology, 40(1).

Noor, S., Qousain, S. T., & Muhammad, S. A. (2019). In silico docking analysis of CCL28 (CC motif chemokine ligand 28) and astragalin as the potential inhibitor of rheumatoid arthritis. F1000Research, 8(313), 313.

Wang, P., Qi, X., Xu, G., Liu, J., Guo, J., Li, X., ... & Sun, H. (2019). CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY), 11(18), 7402.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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