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Mouse Anti-CCL28 Recombinant Antibody (CBXC-1266) (CBMAB-C5789-CQ)

This product is a mouse antibody that recognizes CCL28. The antibody CBXC-1266 can be used for immunoassay techniques such as: WB, ELISA(Cap).
See all CCL28 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1266
Antibody Isotype
IgG1
Application
WB, ELISA(Cap)

Basic Information

Immunogen
E. coli-derived recombinant human CCL28, Ile23-Tyr127, Accession # Q9NRJ3
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 28
Introduction
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
56477
UniProt ID
Q9NRJ3
Alternative Names
C-C Motif Chemokine Ligand 28; Mucosae-Associated Epithelial Chemokine; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28; Small Inducible Cytokine A28; CC Chemokine CCL28; SCYA28; MEC;
Function
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Chemotaxis Source: UniProtKB
Cytolysis in other organism Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: InterPro
Killing of cells of other organism Source: UniProtKB
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Response to nutrient Source: Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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