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Mouse Anti-CD52 Recombinant Antibody (CBXS-2338) (CBMAB-S5097-CQ)

This product is a mouse antibody that recognizes CD52. The antibody CBXS-2338 can be used for immunoassay techniques such as: FC.
See all CD52 antibodies

Summary

Host Animal
Mouse
Specificity
Pig
Clone
CBXS-2338
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Pig peripheral blood mononuclear cells
Specificity
Pig
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD52 Molecule
Introduction
CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes and dendritic cells.Further, it is found within the male genital tract and is present on the surface of mature sperm cells. CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.
Entrez Gene ID
100873164
UniProt ID
H8ZRT6
Alternative Names
CD52 molecule
Function
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Biological Process
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Respiratory burst Source: UniProtKB
Cellular Location
Cell membrane

Frota, N. F., de Sousa Rebouças, A., Fuzo, C. A., & Lourenzoni, M. R. (2021). Alemtuzumab scFv fragments and CD52 interaction study through molecular dynamics simulation and binding free energy. Journal of Molecular Graphics and Modelling, 107949.

Mao, R., Yang, F., Zhang, Y., Liu, H., Guo, P., Liu, Y., & Zhang, T. (2021). High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes. Aging (Albany NY), 13(8), 11043.

Wang, J., Zhang, G., Sui, Y., Yang, Z., Chu, Y., Tang, H., ... & Wu, C. (2020). CD52 Is a Prognostic Biomarker and Associated With Tumor Microenvironment in Breast Cancer. Frontiers in Genetics, 11, 1350.

Bhamidipati, K., Silberstein, J. L., Chaichian, Y., Baker, M. C., Lanz, T. V., Zia, A., ... & Robinson, W. H. (2020). CD52 is Elevated on B cells of SLE Patients and Regulates B Cell Function. Frontiers in Immunology, 11, 3736.

Shathili, A. M., Bandala-Sanchez, E., John, A., Goddard-Borger, E. D., Thaysen-Andersen, M., Everest-Dass, A. V., ... & Packer, N. H. (2019). Specific sialoforms required for the immune suppressive activity of human soluble CD52. Frontiers in immunology, 10, 1967.

Zheng, C., Zhuang, C., Chen, Y., Fu, Q., Qian, H., Wang, Y., ... & Qi, N. (2018). Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture. Process Biochemistry, 65, 123-129.

Simon, M., Ipek, R., Homola, G. A., Rovituso, D. M., Schampel, A., Kleinschnitz, C., & Kuerten, S. (2018). Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis. Journal of neuroinflammation, 15(1), 1-15.

Rashidi, M., Bandala-Sanchez, E., Lawlor, K. E., Zhang, Y., Neale, A. M., Vijayaraj, S. L., ... & Harrison, L. C. (2018). CD52 inhibits Toll-like receptor activation of NF-κ B and triggers apoptosis to suppress inflammation. Cell Death & Differentiation, 25(2), 392-405.

Bandala-Sanchez, E., Bediaga, N. G., Goddard-Borger, E. D., Ngui, K., Naselli, G., Stone, N. L., ... & Harrison, L. C. (2018). CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function. Proceedings of the National Academy of Sciences, 115(30), 7783-7788.

Zhao, Y., Su, H., Shen, X., Du, J., Zhang, X., & Zhao, Y. (2017). The immunological function of CD52 and its targeting in organ transplantation. Inflammation Research, 66(7), 571-578.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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