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Mouse Anti-CDC37 Recombinant Antibody (AP1357) (CBMAB-AP1357LY)


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Published Data
CBMAB-AP1357LY-1
Mouse Anti-CDC37 Recombinant Antibody (AP1357) (CBMAB-AP1357LY) in Immunoblot and IP
IP of endogenous Cdc37 and blot for transfected FGFR3 (V5) in 293 cells. ...View More
Laederich, M. B., Degnin, C. R., Lunstrum, G. P., Holden, P., & Horton, W. A. (2011). Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation. Journal of Biological Chemistry, 286(22), 19597-19604.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-AP1357LY-2
Mouse Anti-CDC37 Recombinant Antibody (AP1357) (CBMAB-AP1357LY) in Immunoblot and IP
Transfection of empty vector (V) or FGFR1-4 V5 in 293 cells followed by V5 IP and blotting. An arrow denotes the Cdc37 band running just below the IgG heavy chain. ...View More
Laederich, M. B., Degnin, C. R., Lunstrum, G. P., Holden, P., & Horton, W. A. (2011). Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation. Journal of Biological Chemistry, 286(22), 19597-19604.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human
Clone
AP1357
Antibody Isotype
IgG2b, κ
Application
WB, IF, IP, IHC-P, ELISA

Basic Information

Immunogen
Amino acids 108-378 of Cdc37 of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Division Cycle 37
Introduction
CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Aryl Hydrocarbon Receptor and Signaling by Ligand-Responsive EGFR Variants in Cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.
Entrez Gene ID
Human11140
Mouse12539
Rat114562
UniProt ID
HumanQ16543
MouseQ61081
RatQ63692
Alternative Names
Cell Division Cycle 37; CDC37 (Cell Division Cycle 37, S. Cerevisiae, Homolog); Hsp90 Chaperone Protein Kinase-Targeting Subunit; CDC37 Cell Division Cycle 37 Homolog; Hsp90 Co-Chaperone Cdc37; P50CDC37;
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233).
Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Biological Process
ERBB2 signaling pathway Source: Reactome
Positive regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Posttranscriptional regulation of gene expression Source: Ensembl
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Protein targeting Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of interferon-gamma-mediated signaling pathway Source: MGI
Regulation of necroptotic process Source: Reactome
Regulation of type I interferon-mediated signaling pathway Source: MGI
Cellular Location
Cytoplasm
PTM
Constitutively sumoylated by UBE2I.
More Infomation

Zhang, Q., Wu, Y. F., Chen, P., Liu, T. H., Dong, Z. Q., Lu, C., & Pan, M. H. (2021). Bombyx mori cell division cycle protein 37 promotes the proliferation of BmNPV. Pesticide Biochemistry and Physiology, 178, 104923.

Wang, L., Zhang, Q., & You, Q. (2021). Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer. Medicinal Research Reviews.

Zang, M. R., Liu, L. T., Deng, S. H., & Qiu, L. G. (2021). Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation. Zhongguo shi yan xue ye xue za zhi, 29(5), 1522-1527.

Chen, C., Wang, Y. S., Zhang, E. T., Li, G. A., Liu, W. Y., Li, Y., & Jin, Y. H. (2021). (20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells. International Journal of Molecular Sciences, 22(23), 13170.

Wang, L., Jiang, J., Zhang, L., Zhang, Q., Zhou, J., Li, L., ... & You, Q. (2020). Discovery and optimization of small molecules targeting the protein–protein interaction of heat shock protein 90 (Hsp90) and cell division cycle 37 as orally active inhibitors for the treatment of colorectal cancer. Journal of medicinal chemistry, 63(3), 1281-1297.

Zhu, J., Yan, F., Tao, J., Zhu, X., Liu, J., Deng, S., & Zhang, X. (2018). Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK 4 signaling pathway. Cancer science, 109(3), 656-665.

Li, R., Yuan, F., Fu, W., Zhang, L., Zhang, N., Wang, Y., ... & Zhao, Y. (2017). Serine/threonine kinase Unc-51-like kinase-1 (Ulk1) phosphorylates the co-chaperone cell division cycle protein 37 (Cdc37) and thereby disrupts the stability of Cdc37 client proteins. Journal of Biological Chemistry, 292(7), 2830-2841.

Chen, B., Wei, W., Ma, L., Yang, B., Gill, R. M., Chua, M. S., ... & So, S. (2017). Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells in vitro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology, 152(8), 2022-2036.

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For research use only. Not intended for any clinical use.

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