Mouse Recombinant CDC37 protein, GST Tag (V2LY-0526-LY8089)

Name: Mouse Recombinant CDC37 protein, GST Tag
SKU: V2LY-0526-LY8089
Rating: 5 (1 reviews)

See all CDC37 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Mouse

Tag

GST Tag

Protein Construction

This product is Mouse Recombinant CDC37 protein, GST Tag consist of Amino Acid: 1-379 and predicts a molecular mass of 72.4 kDa.

Molecule Mass

72.4 kDa

Sequence

Amino Acid: 1-379

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cell Division Cycle 37

Function

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233).
Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Biological Process

ERBB2 signaling pathway Source: Reactome
Positive regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Posttranscriptional regulation of gene expression Source: Ensembl
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Protein targeting Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of interferon-gamma-mediated signaling pathway Source: MGI
Regulation of necroptotic process Source: Reactome
Regulation of type I interferon-mediated signaling pathway Source: MGI

Cellular Location

Cytoplasm

PTM

Constitutively sumoylated by UBE2I.

Zhang, Q., Wu, Y. F., Chen, P., Liu, T. H., Dong, Z. Q., Lu, C., & Pan, M. H. (2021). Bombyx mori cell division cycle protein 37 promotes the proliferation of BmNPV. Pesticide Biochemistry and Physiology, 178, 104923.

Wang, L., Zhang, Q., & You, Q. (2021). Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer. Medicinal Research Reviews.

Zang, M. R., Liu, L. T., Deng, S. H., & Qiu, L. G. (2021). Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation. Zhongguo shi yan xue ye xue za zhi, 29(5), 1522-1527.

Chen, C., Wang, Y. S., Zhang, E. T., Li, G. A., Liu, W. Y., Li, Y., & Jin, Y. H. (2021). (20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells. International Journal of Molecular Sciences, 22(23), 13170.

Wang, L., Jiang, J., Zhang, L., Zhang, Q., Zhou, J., Li, L., ... & You, Q. (2020). Discovery and optimization of small molecules targeting the protein–protein interaction of heat shock protein 90 (Hsp90) and cell division cycle 37 as orally active inhibitors for the treatment of colorectal cancer. Journal of medicinal chemistry, 63(3), 1281-1297.

Zhu, J., Yan, F., Tao, J., Zhu, X., Liu, J., Deng, S., & Zhang, X. (2018). Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK 4 signaling pathway. Cancer science, 109(3), 656-665.

Li, R., Yuan, F., Fu, W., Zhang, L., Zhang, N., Wang, Y., ... & Zhao, Y. (2017). Serine/threonine kinase Unc-51-like kinase-1 (Ulk1) phosphorylates the co-chaperone cell division cycle protein 37 (Cdc37) and thereby disrupts the stability of Cdc37 client proteins. Journal of Biological Chemistry, 292(7), 2830-2841.

Chen, B., Wei, W., Ma, L., Yang, B., Gill, R. M., Chua, M. S., ... & So, S. (2017). Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells in vitro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology, 152(8), 2022-2036.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Recombinant CDC37 protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CDC37 protein, GST Tag (CAT#: V2LY-0526-LY2996)

Mouse Recombinant CDC37 protein (CAT#: V2LY-0526-LY8088)

Related Products

Mouse Anti-CDC37 Recombinant Antibody (CBT3739) (CAT#: V2LY-0625-LY646)

Mouse Anti-CDC37 Recombinant Antibody (CBFYC-1518) (CAT#: CBMAB-C1577-FY)

Human Recombinant CDC37 protein, GST Tag (CAT#: V2LY-0526-LY2996)

Rabbit Anti-CDC37 Recombinant Antibody (CBNH-126) (CAT#: CBMAB-R4451-CN)

Mouse Anti-CDC37 Recombinant Antibody (CBT2976) (CAT#: V2LY-0625-LY647)

Mouse Anti-CDC37 Recombinant Antibody (3C7) (CAT#: CBMAB-C5824-LY)

Mouse Anti-CDC37 Recombinant Antibody (AP1357) (CAT#: CBMAB-AP1357LY)

Rabbit Anti-CDC37 Recombinant Antibody (
10C3) (CAT#: V2LY-0725-LY1540)

Mouse Recombinant CDC37 protein (CAT#: V2LY-0526-LY8088)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry