Mouse Anti-CDC37 Recombinant Antibody (CBT3739) (V2LY-0625-LY646)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBT3739
Application
WB
Immunogen
Purified recombinant fragment of human CDC37 (AA: 241-378) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cell Division Cycle 37
Entrez Gene ID
UniProt ID
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233).
Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Biological Process
ERBB2 signaling pathway Source: Reactome
Positive regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Posttranscriptional regulation of gene expression Source: Ensembl
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Protein targeting Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of interferon-gamma-mediated signaling pathway Source: MGI
Regulation of necroptotic process Source: Reactome
Regulation of type I interferon-mediated signaling pathway Source: MGI
Cellular Location
Cytoplasm
PTM
Constitutively sumoylated by UBE2I.

Zhang, Q., Wu, Y. F., Chen, P., Liu, T. H., Dong, Z. Q., Lu, C., & Pan, M. H. (2021). Bombyx mori cell division cycle protein 37 promotes the proliferation of BmNPV. Pesticide Biochemistry and Physiology, 178, 104923.

Wang, L., Zhang, Q., & You, Q. (2021). Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer. Medicinal Research Reviews.

Zang, M. R., Liu, L. T., Deng, S. H., & Qiu, L. G. (2021). Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation. Zhongguo shi yan xue ye xue za zhi, 29(5), 1522-1527.

Chen, C., Wang, Y. S., Zhang, E. T., Li, G. A., Liu, W. Y., Li, Y., & Jin, Y. H. (2021). (20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells. International Journal of Molecular Sciences, 22(23), 13170.

Wang, L., Jiang, J., Zhang, L., Zhang, Q., Zhou, J., Li, L., ... & You, Q. (2020). Discovery and optimization of small molecules targeting the protein–protein interaction of heat shock protein 90 (Hsp90) and cell division cycle 37 as orally active inhibitors for the treatment of colorectal cancer. Journal of medicinal chemistry, 63(3), 1281-1297.

Zhu, J., Yan, F., Tao, J., Zhu, X., Liu, J., Deng, S., & Zhang, X. (2018). Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK 4 signaling pathway. Cancer science, 109(3), 656-665.

Li, R., Yuan, F., Fu, W., Zhang, L., Zhang, N., Wang, Y., ... & Zhao, Y. (2017). Serine/threonine kinase Unc-51-like kinase-1 (Ulk1) phosphorylates the co-chaperone cell division cycle protein 37 (Cdc37) and thereby disrupts the stability of Cdc37 client proteins. Journal of Biological Chemistry, 292(7), 2830-2841.

Chen, B., Wei, W., Ma, L., Yang, B., Gill, R. M., Chua, M. S., ... & So, S. (2017). Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells in vitro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology, 152(8), 2022-2036.

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For research use only. Not intended for any clinical use.

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