Mouse Anti-CDKN3 Recombinant Antibody (CBFYC-1651) (CBMAB-C1712-FY)

Name: Mouse Anti-CDKN3 Recombinant Antibody (CBFYC-1651)
SKU: CBMAB-C1712-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1651

Application

WB, IP, IF

Immunogen

Amino acids 1-212 representing full length CDKN3 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin Dependent Kinase Inhibitor 3

Introduction

Cyclin-dependent kinase inhibitor 3 (CDKN3) has been reported to promote tumor genesis.

Entrez Gene ID

1033

UniProt ID

Q16667

Alternative Names

Cyclin Dependent Kinase Inhibitor 3; CDK2-Associated Dual Specificity Phosphatase; Cyclin-Dependent Kinase Interactor 1; Cyclin-Dependent Kinase Inhibitor; Kinase-Associated Phosphatase; CDI1; CIP2; KAP; Cyclin-Dependent Kinase Interacting Protein 2

Function

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.

Biological Process

Cell cycle arrest Source: MGI
G1/S transition of mitotic cell cycle Source: ProtInc
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc

Cellular Location

Perinuclear region

Involvement in disease

Hepatocellular carcinoma (HCC): A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Mamoor, S. (2021). Over-expression of cyclin dependent kinase inhibitor 3 in human endometrial cancer.

Mamoor, S. (2021). Differential expression of cyclin dependent kinase inhibitor 3 in human epithelial ovarian cancer.

Cen, J., Liang, Y., Huang, Y., Pan, Y., Shu, G., Zheng, Z., ... & Zhang, J. (2021). Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis. Molecular cancer, 20(1), 1-14.

Li, W., Liu, D., Tang, S., Li, D., Han, R., Tian, Y., ... & Li, Z. (2019). A multiallelic indel in the promoter region of the Cyclin-dependent kinase inhibitor 3 gene is significantly associated with body weight and carcass traits in chickens. Poultry science, 98(2), 556-565.

Liu, J., Min, L., Zhu, S., Guo, Q., Li, H., Zhang, Z., ... & Zhang, S. (2019). Cyclin-dependent kinase inhibitor 3 promoted cell proliferation by driving cell cycle from G1 to S phase in esophageal squamous cell carcinoma. Journal of Cancer, 10(8), 1915.

Cress, W. D., Yu, P., & Wu, J. (2017). Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. The international journal of biochemistry & cell biology, 91, 98-101.

Yu, C., Cao, H., He, X., Sun, P., Feng, Y., Chen, L., & Gong, H. (2017). Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Biomedicine & Pharmacotherapy, 96, 1109-1118.

Li, Y., Ji, S., Fu, L. Y., Jiang, T., Wu, D., & Meng, F. D. (2017). Knockdown of cyclin-dependent kinase inhibitor 3 inhibits proliferation and invasion in human gastric cancer cells. Oncology research, 25(5), 721.

Wang, H., Chen, H., Zhou, H., Yu, W., & Lu, Z. (2017). Cyclin-dependent kinase inhibitor 3 promotes cancer cell proliferation and tumorigenesis in nasopharyngeal carcinoma by targeting p27. Oncology research, 25(9), 1431.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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