Human Recombinant CDKN3 protein, GST Tag (V2LY-0526-LY3073)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant CDKN3 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 51 kDa.
Molecule Mass
51 kDa
Sequence
Amino Acid: Full Length
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Cyclin Dependent Kinase Inhibitor 3
Function
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Biological Process
Cell cycle arrest Source: MGI
G1/S transition of mitotic cell cycle Source: ProtInc
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Cellular Location
Perinuclear region
Involvement in disease
Hepatocellular carcinoma (HCC): A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Mamoor, S. (2021). Over-expression of cyclin dependent kinase inhibitor 3 in human endometrial cancer.

Mamoor, S. (2021). Differential expression of cyclin dependent kinase inhibitor 3 in human epithelial ovarian cancer.

Cen, J., Liang, Y., Huang, Y., Pan, Y., Shu, G., Zheng, Z., ... & Zhang, J. (2021). Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis. Molecular cancer, 20(1), 1-14.

Li, W., Liu, D., Tang, S., Li, D., Han, R., Tian, Y., ... & Li, Z. (2019). A multiallelic indel in the promoter region of the Cyclin-dependent kinase inhibitor 3 gene is significantly associated with body weight and carcass traits in chickens. Poultry science, 98(2), 556-565.

Liu, J., Min, L., Zhu, S., Guo, Q., Li, H., Zhang, Z., ... & Zhang, S. (2019). Cyclin-dependent kinase inhibitor 3 promoted cell proliferation by driving cell cycle from G1 to S phase in esophageal squamous cell carcinoma. Journal of Cancer, 10(8), 1915.

Cress, W. D., Yu, P., & Wu, J. (2017). Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. The international journal of biochemistry & cell biology, 91, 98-101.

Yu, C., Cao, H., He, X., Sun, P., Feng, Y., Chen, L., & Gong, H. (2017). Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Biomedicine & Pharmacotherapy, 96, 1109-1118.

Li, Y., Ji, S., Fu, L. Y., Jiang, T., Wu, D., & Meng, F. D. (2017). Knockdown of cyclin-dependent kinase inhibitor 3 inhibits proliferation and invasion in human gastric cancer cells. Oncology research, 25(5), 721.

Wang, H., Chen, H., Zhou, H., Yu, W., & Lu, Z. (2017). Cyclin-dependent kinase inhibitor 3 promotes cancer cell proliferation and tumorigenesis in nasopharyngeal carcinoma by targeting p27. Oncology research, 25(9), 1431.

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For research use only. Not intended for any clinical use.

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