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Mouse Anti-CDKN3 Recombinant Antibody (CBFYC-1652) (CBMAB-C1713-FY)

This product is mouse antibody that recognizes CDKN3. The antibody CBFYC-1652 can be used for immunoassay techniques such as: FC, IF, IHC, WB.
See all CDKN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1652
Antibody Isotype
IgG1
Application
FC, IF, IHC, WB

Basic Information

Immunogen
Full-length recombinant protein of human CDKN3 (NP_005183) produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase Inhibitor 3
Introduction
Cyclin-dependent kinase inhibitor 3 (CDKN3) has been reported to promote tumor genesis.
Entrez Gene ID
1033
UniProt ID
Q16667
Alternative Names
Cyclin Dependent Kinase Inhibitor 3; CDK2-Associated Dual Specificity Phosphatase; Cyclin-Dependent Kinase Interactor 1; Cyclin-Dependent Kinase Inhibitor; Kinase-Associated Phosphatase; CDI1; CIP2; KAP; Cyclin-Dependent Kinase Interacting Protein 2
Function
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Biological Process
Cell cycle arrest Source: MGI
G1/S transition of mitotic cell cycle Source: ProtInc
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Cellular Location
Perinuclear region
Involvement in disease
Hepatocellular carcinoma (HCC): A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Mamoor, S. (2021). Over-expression of cyclin dependent kinase inhibitor 3 in human endometrial cancer.

Mamoor, S. (2021). Differential expression of cyclin dependent kinase inhibitor 3 in human epithelial ovarian cancer.

Cen, J., Liang, Y., Huang, Y., Pan, Y., Shu, G., Zheng, Z., ... & Zhang, J. (2021). Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis. Molecular cancer, 20(1), 1-14.

Li, W., Liu, D., Tang, S., Li, D., Han, R., Tian, Y., ... & Li, Z. (2019). A multiallelic indel in the promoter region of the Cyclin-dependent kinase inhibitor 3 gene is significantly associated with body weight and carcass traits in chickens. Poultry science, 98(2), 556-565.

Liu, J., Min, L., Zhu, S., Guo, Q., Li, H., Zhang, Z., ... & Zhang, S. (2019). Cyclin-dependent kinase inhibitor 3 promoted cell proliferation by driving cell cycle from G1 to S phase in esophageal squamous cell carcinoma. Journal of Cancer, 10(8), 1915.

Cress, W. D., Yu, P., & Wu, J. (2017). Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. The international journal of biochemistry & cell biology, 91, 98-101.

Yu, C., Cao, H., He, X., Sun, P., Feng, Y., Chen, L., & Gong, H. (2017). Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Biomedicine & Pharmacotherapy, 96, 1109-1118.

Li, Y., Ji, S., Fu, L. Y., Jiang, T., Wu, D., & Meng, F. D. (2017). Knockdown of cyclin-dependent kinase inhibitor 3 inhibits proliferation and invasion in human gastric cancer cells. Oncology research, 25(5), 721.

Wang, H., Chen, H., Zhou, H., Yu, W., & Lu, Z. (2017). Cyclin-dependent kinase inhibitor 3 promotes cancer cell proliferation and tumorigenesis in nasopharyngeal carcinoma by targeting p27. Oncology research, 25(9), 1431.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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