Mouse Anti-CEACAM5 Recombinant Antibody (CBT311) (V2LY-0625-LY3609)

Name: Mouse Anti-CEACAM5 Recombinant Antibody (CBT311)
SKU: V2LY-0625-LY3609
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CEACAM5 Recombinant Antibody (CBT311) (V2LY-0625-LY3609) in IHC

Mouse Anti-CEACAM5 Recombinant Antibody (CBT311) (V2LY-0625-LY3609) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT311

Application

WB, IHC-P, IF, ELISA

Immunogen

Purified recombinant fragment of human CD66e expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
IHC	1:200-1:1,000
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Buffer

BSA, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 5

Entrez Gene ID

1048

UniProt ID

P06731

Function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Biological Process

Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of myotube differentiation Source: UniProtKB

Cellular Location

Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.

PTM

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Scoazec, J. Y., Bauchet, A. L., Adam, J., Rochaix, P., MacGrogan, G., Kim, J. E., ... & Lefebvre, A. M. (2021). 1313P Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) tumor expression in a phase I/II study of tusamitamab ravtansine (SAR408701) in patients (pts) with advanced non-small cell lung cancer (NSCLC). Annals of Oncology, 32, S1011.

Adam, J., Lefebvre, A. M., Nicolazzi, C., Larois, C., Attenot, F., Falda-Buscaiot, F., ... & Henry, C. (2021). 19P Therapeutic targets in non-small cell lung cancer: Preclinical and human studies of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and its associated molecular landscape. Annals of Oncology, 32, S1381.

Gazzah, A., Ricordel, C., Cousin, S., Cho, B. C., Calvo, E., Kim, T. M., ... & Barlesi, F. (2020). Efficacy and safety of the antibody-drug conjugate (ADC) SAR408701 in patients (pts) with non-squamous non-small cell lung cancer (NSQ NSCLC) expressing carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5).

Wan, W., Ye, Y., Wang, H., Li, L., Gu, Y., Yang, L., ... & Meng, Z. (2019). Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 9864.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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