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CEACAM5

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 5
Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Biological Process
Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of myotube differentiation Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.
PTM
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
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Anti-CEACAM5 antibodies

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Human Anti-CEACAM5 Recombinant Antibody (CBXC-0933) (CBMAB-C2049-CQ)

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Target: CEACAM5
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0933
Application*: WB, F, E, in vivo
In Vivo Assay
Datasheet SDS

Rabbit Anti-CEACAM5 Recombinant Antibody (CBYY-C0493) (CBMAB-C1465-YY)

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Target: CEACAM5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C0493
Application*: P
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBFYC-1678) (CBMAB-C1740-FY)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1678
Application*: in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CB30) (CBMAB-C0524-CQ)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB30
Application*: WB, IF, F, IP
Datasheet SDS

Rabbit Anti-CEACAM5 Recombinant Antibody (CBFYC-1686) (CBMAB-C1748-FY)

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Target: CEACAM5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1686
Application*: F
Datasheet SDS

Human Anti-CEACAM5 Recombinant Antibody (CBFYC-1681) (CBMAB-C1743-FY)

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Target: CEACAM5
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1681
Application*: IH, F, IF
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBFYC-1680) (CBMAB-C1742-FY)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1680
Application*: IH, WB
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBFYC-1679) (CBMAB-C1741-FY)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-1679
Application*: E, P
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBFYC-0318) (CBMAB-C0354-FY)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0318
Application*: WB, IF, F, IP, E
Datasheet SDS

Rabbit Anti-CEACAM5 Recombinant Antibody (CBFYC-0054) (CBMAB-C0061-FY)

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Target: CEACAM5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0054
Application*: E
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT256) (V2LY-0625-LY3661)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT256
Application*: P, IF, IC
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT310) (V2LY-0625-LY3610)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT310
Application*: WB, IF, IC, E
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT311) (V2LY-0625-LY3609)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT311
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT2937) (V2LY-0625-LY2574)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2937
Application*: IC
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT3378) (V2LY-0625-LY2573)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3378
Application*: IH
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT2339) (V2LY-0625-LY2023)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2339
Application*: IH
Datasheet SDS

Mouse Anti-CEACAM5 Recombinant Antibody (CBT2182) (V2LY-0625-LY1036)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2182
Application*: F
Datasheet SDS

Mouse Anti-CEACAM5 Monoclonal Antibody (CBFYR-0009) (CBMAB-R0015-FY)

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Target: CEACAM5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYR-0009
Application*: WB, IF, F, IP, P
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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