Mouse Anti-CLTB Recombinant Antibody (4B12-1E3) (V2LY-1206-LY307)

Name: Mouse Anti-CLTB Recombinant Antibody (4B12-1E3)
SKU: V2LY-1206-LY307
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CLTB Recombinant Antibody (4B12-1E3) (V2LY-1206-LY307) in Immunoblot

Immunoblot with CLCb antibody of non-transfected and transfected HeLa cells. ...View More

Obashi, K., Sochacki, K. A., Strub, M. P., & Taraska, J. W. (2023). A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells. Biophysical Journal, 122(3), 460a.

Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B12-1E3

Application

WB, IHC, IF, ELISA

Immunogen

Full length recombinant CLTB.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Clathrin Light Chain B

Entrez Gene ID

1212

UniProt ID

P09497

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Biological Process

Clathrin coat assembly Source: GO_Central
Clathrin-dependent endocytosis Source: GO_Central
Intracellular protein transport Source: InterPro
Membrane organization Source: Reactome

Cellular Location

Cytoplasmic vesicle membrane; Coated pit. Cytoplasmic face of coated pits and vesicles.

Mukenhirn, M., Muraca, F., Bucher, D., Asberger, E., Cappio Barazzone, E., Cavalcanti-Adam, E. A., & Boulant, S. (2021). Role of Clathrin Light Chains in Regulating Invadopodia Formation. Cells, 10(2), 451.

Redlingshöfer, L., & Brodsky, F. M. (2021). Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains. Cells & Development, 203714.

Redlingshöfer, L., McLeod, F., Chen, Y., Camus, M. D., Burden, J. J., Palomer, E., ... & Brodsky, F. M. (2020). Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. Proceedings of the National Academy of Sciences, 117(38), 23527-23538.

Khasa, R., Vaidya, A., Vrati, S., & Kalia, M. (2019). Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells. Journal of General Virology, 100(2), 176-186.

Li, Y., Liu, H., Wu, K., Liu, H., Huang, T., Chen, Z. J., ... & Zhao, H. (2019). Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin‐mediated endocytosis. Journal of Pineal Research, 67(3), e12601.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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