Mouse Anti-CNN2 Recombinant Antibody (CBWJC-2859) (V2LY-1206-LY442)

Name: Mouse Anti-CNN2 Recombinant Antibody (CBWJC-2859)
SKU: V2LY-1206-LY442
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CNN2 Recombinant Antibody (CBWJC-2859) (V2LY-1206-LY442) in IHC

Immunohistochemical detection of proliferation and remodeling marker proteins including smooth muscle a-actin (SMAα), calponin, osteopontin (OPN), and proliferating cell nuclear antigen (PCNA) in the media of thoracic aorta in rats (200 ×). ...View More

Qu, Y. Y., Hui, J., Wang, L. M., Tang, N., Zhong, H., Liu, Y. M., ... & He, F. (2016). Reduced expression of the extracellular calcium-sensing receptor (CaSR) is associated with activation of the renin-angiotensin system (RAS) to promote vascular remodeling in the pathogenesis of essential hypertension. PloS one, 11(7), e0157456.

Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2859

Application

WB, IHC, IF

Immunogen

Turkey gizzard calponin.

Host Species

Mouse

Specificity

Human, Chicken, Turkey

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.25-0.5 μg/ml
IHC	0.5-1 μg/ml
IF(ICC)	1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Calponin 2

Entrez Gene ID

1265

UniProt ID

Q99439

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Biological Process

Actomyosin structure organization Source: InterPro
Cellular response to mechanical stimulus Source: MGI
Cytoskeleton organization Source: ProtInc
Interleukin-12-mediated signaling pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Regulation of actin filament-based process Source: MGI

Cellular Location

Cytoskeleton; Stress fiber; Extracellular region; Cell-cell junction; Focal adhesion; Membrane; Specific granule lumen; Tertiary granule lumen

Jang, I., & Jin, J. P. (2022). Role of calponin 2 in cell migration and mechanoregulation. Biophysical Journal, 121(3), 266a.

Zhang, R., Li, S., Wang, Y., Cai, W., Liu, Q., & Zhang, J. (2021). Serum calponin 2 is a novel biomarker of tubal ectopic pregnancy. Fertility and Sterility, 116(4), 1020-1027.

Plazyo, O., Hao, W., & Jin, J. P. (2020). The absence of calponin 2 in rabbits suggests caution in choosing animal models. Frontiers in bioengineering and biotechnology, 8, 42.

Plazyo, O., Sheng, J. J., & Jin, J. P. (2019). Downregulation of calponin 2 contributes to the quiescence of lung macrophages. American Journal of Physiology-Cell Physiology, 317(4), C749-C761.

Feng, H. Z., Wang, H., Takahashi, K., & Jin, J. P. (2019). Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. Journal of molecular and cellular cardiology, 129, 49-57.

Li, Y., Ding, X., Xiu, S., Du, G., & Liu, Y. (2019). LncRNA NEAT1 promotes proliferation, migration and invasion via regulating miR-296-5p/CNN2 axis in hepatocellular carcinoma cells. OncoTargets and therapy, 12, 9887.

Plazyo, O., Liu, R., Hossain, M. M., & Jin, J. P. (2018). Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE−/− mice. Journal of Molecular and Cellular Cardiology, 121, 233-241.

Kang, X., Wang, F., Lan, X., Li, X., Zheng, S., Lv, Z., ... & Zhou, S. (2018). Lentivirus-mediated shRNA targeting CNN2 inhibits hepatocarcinoma in vitro and in vivo. International journal of medical sciences, 15(1), 69.

Hu, J., Xie, W., Shang, L., Yang, X., Li, Q., Xu, M., ... & Wu, Y. (2017). Knockdown of calponin 2 suppressed cell growth in gastric cancer cells. Tumor Biology, 39(7), 1010428317706455.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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